ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neuro-Otology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1595887
Risk Factors and Nomogram Model for Recurrence of Benign Paroxysmal Positional Vertigo in Postmenopausal Women: A Multicenter Cross-sectional Study
Provisionally accepted
- 1川北医学院附属医院, 中国 四川 南充, China
- 2Affiliated Hospital of North Sichuan Medical College,, nanchong, China
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Objective: To explore the risk factors for recurrent benign paroxysmal positional vertigo (BPPV) in postmenopausal women within one year of canalith repositioning procedure (CRP), and develops a risk model based on serum 25-hydroxyvitamin D (25(OH)D), estradiol, and calcium levels to provide early identification of high-risk groups and guide prevention and treatment strategies. Methods: Data from postmenopausal women with BPPV, diagnosed and successfully treated with CRP at five hospitals in Sichuan Province between January 2019 and January 2024, were retrospectively analyzed. Participants were divided into BPPV validation and training sets in a 3:7 ratio. Clinical data were categorized into recurrence and non-recurrence subgroups based on whether BPPV recurred after treatment. LASSO regression identified factors influencing recurrence within one year after CRP, and multivariate logistic regression (MLR) analysis was used to develop a risk nomogram prediction model (NPM). Results: A total of 490 patients were enrolled, with 147 in the validation set and 343 in the training sets,. Among them, 151 patients (30.82%) experienced recurrenced, including 58 (30.61%) in the validation set and 106 (30.90%) in the training sets,. LASSO and MLR analyses identified migraine (OR=2.208, 95%CI=1.278-3.817), serum calcium (OR=0.601, 95%CI=0.447-0.81), 25(OH)D (OR=0.785, 95%CI=0.713-0.864), and serum estradiol (OR=0.820,95%CI=0.752-0.894) as significant factors influencing recurrence within one year after CRP treatment in postmenopausal women with BPPV.. Conclusion: The recurrence rate of BPPV within one year after CRP treatment in postmenopausal women is high. Migraine, 25(OH)D, calcium, and estradiol are associated with recurrence. The risk prediction model, developed using these factors, demonstrates good discrimination and calibration. It effectively predicts the recurrence risk within one year after successful CRP treatment, offering practical clinical value.
Keywords: canalith repositioning procedure, benign paroxysmal positional vertigo, postmenopausal women, Estradiol, 25(OH)D, Calcium, nomogram
Received: 19 Mar 2025; Accepted: 28 Apr 2025.
Copyright: © 2025 Qing-chun, Li and Kai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bei Li, Affiliated Hospital of North Sichuan Medical College,, nanchong, China
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