REVIEW article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1596940
Blood-based Biomarkers and Neuroimaging for Early Detection of Post-Stroke Cognitive Impairment: Current Evidence and Synergistic Prospects
Provisionally accepted
- The Fifth Affiliated Hospital of Kunming Medical University, Gejiu, China
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Post stroke cognitive impairment (PSCI) is a series of common complications caused by stroke, ranging from mild cognitive impairment to dementia, which seriously affects the recovery and living quality of patients. Currently, the diagnosis of PSCI in the clinic mostly relies on subjective scale assessment, the untimeliness and imprecision of results greatly limit the efficient identification as well as the subsequent diagnosis and treatment of PSCI. With the increasing popularity and optimization of bioassay techniques and equipment, more and more studies have identified potential early warning markers of stroke patients with the development of their cognitive deficits through hematological testing or imaging. Therefore, the application of blood-based biomarkers and imaging techniques is important for the early identification of PSCI. This review focuses on the research progress of the above two testing modalities in PSCI to discuss their vital meanings for disease recognition. It also suggests that the combined application of the two is expected to improve the potential value of early and accurate diagnosis, with a view to providing new ideas for the clinical diagnosis and treatment of PSCI.
Keywords: post-stroke cognitive impairment, Blood-based testing, biomarkers, Neuroimaging, diagnosis
Received: 22 Mar 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 Li, Xin, Li, Yao and Su. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ping Li, The Fifth Affiliated Hospital of Kunming Medical University, Gejiu, China
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