SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Neurorehabilitation
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1598974
This article is part of the Research TopicNew approaches for central nervous system rehabilitation - Volume IIView all 6 articles
Summary of the Best Evidence for Non-pharmaceutical Interventions for Mild Cognitive Impairment in Parkinson's Disease
Provisionally accepted
- 1Yunnan University of Traditional Chinese Medicine, Kunming, China
- 2Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, Yunnan Province, China
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Objective: To synthesize and evaluate the best evidence for non-pharmacological interventions targeting mild cognitive impairment in Parkinson's disease (PD-MCI), thereby informing the development of cognitive management strategies for this population. Methods: A systematic search was conducted across multiple databases (e.g., UpToDate, BMJ Best Practice, Cochrane Library) up to November 2024. Two researchers independently screened literature, assessed quality using standardized tools (AGREE II, JBI criteria), and graded evidence. Results: Thirteen studies were included (5 guidelines, 2 clinical decisions, 2 systematic reviews, 1 meta-analysis, 3 RCTs). Twenty evidence points were categorized into six themes: safety/efficacy, assessment, cognitive training, exercise, health education, and multi-strategy approaches. Conclusion: This study consolidates evidence supporting non-pharmacological interventions for PD-MCI, offering actionable recommendations for clinical practice to delay progression to Parkinson's disease dementia (PDD).
Keywords: Parkinson's disease, Mild Cognitive Impairment, non-pharmacological interventions, evidence summary, Best evidence
Received: 24 Mar 2025; Accepted: 18 Jun 2025.
Copyright: © 2025 Liu, Li, Zhai, Shen, Yang, He and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jinmei Yang, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, Yunnan Province, China
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