REVIEW article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1599978
Psoriasis: an emerging risk factor for ischaemic stroke?
Provisionally accepted
- Medical University of Warsaw, Warsaw, Poland
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In 2020 nearly 12 million people worldwide suffered a stroke, and acute ischaemic stroke (AIS) is the most frequent stroke subtype, accounting for approximately 65% of total stroke incidence. Therefore, primary prevention, including non-traditional risk factors, should be recognized as a major public health priority. Research has shown that autoimmune diseases associated with chronic systemic inflammation, such as psoriasis, are commonly linked to AIS incidence.Psoriasis is a chronic autoimmune erythematous-squamous disease that primarily affects the skin, nails, and joints. Psoriasis is known to be a systemic inflammatory condition affecting multiple organs. Patients with psoriasis are at a higher risk of stroke than the general population, and a more severe disease course can increase this risk by up to 44%. One possible explanation for this phenomenon is that chronic systemic inflammation is associated with endothelial dysfunction and atherosclerotic plaque development. On the other hand, patients with psoriasis have an increased prevalence of traditional cardiovascular risk factors, including metabolic syndrome. This narrative review synthesizes the scientific literature to provide a comprehensive overview of the current understanding of the association between psoriasis and AIS.
Keywords: Acute ischemic stroke, Psoriasis, systemic inflammation, autoimmune erythematous-squamous disease, Traditional cardiovascular risk factors
Received: 25 Mar 2025; Accepted: 29 May 2025.
Copyright: © 2025 Olejnik, Kasarełło, Podkowińska-Polak and Golenia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Aleksandra Golenia, Medical University of Warsaw, Warsaw, Poland
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