ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neuro-Ophthalmology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1600749
Changes in retinal vessel oxygen saturation using automated retinal oximetry in patients with significant carotid stenosis
Provisionally accepted
Petr Polidar1,2*
Barbora Pašková1,2Marta Karhanová1,2Martin Šín1,3
Tomáš Mudroch1,2Tomáš Dorňák1,2Zuzana Schreiberová1,2Petra Divišová1,2
Tomas Veverka1,2David Franc1,2
Petr Hluštík1,2Daniel Šaňák1,2Michal Král1,2*- 1Palacký University, Olomouc, Olomouc, Olomouc, Czechia
- 2University Hospital Olomouc, Olomouc, Czechia
- 3Department of Ophthalmology, First Faculty of Medicine, Charles University, Prague, Prague, Czechia
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Abstract: Purpose: To evaluate the dynamics of changes in retinal oximetry parameters in patients with haemodynamically significant carotid stenosis Methods: In this case-control study we examined 74 eye artery pairs in 37 patients with significant carotid stenosis over 50 % using retinal oximetry. 14 eye artery pairs were excluded due to contraindications for oximetry or presenting carotid occlusion. From the remaining 60 eye artery pairs, 39 eye artery pairs formed the case group, remaining 21 pairs formed control group. Only 16 patients were eligible for bilateral testing to eliminate the possible influence of systemic comorbidities. Linear multiparametric model was used to predict the impact of the stenosis severity on retinal oximetry in context of systemic comorbidities. Results-Paired testing did not show any significant change in AV difference between stenotic and non-stenotic sides in 16 patients eligible for bilateral testing. The predictive model estimated weak correlation between increasing AV difference in increasing stenosis severity, with significant influence of atrial fibrillation and systemic atherosclerosis among noted comorbidities. Conclusion: The relationship between oxygen extraction in retina and increasing severity of the carotid stenosis is weak and modified by various individual factors, notably comorbidities.
Keywords: ischaemic stroke, carotid ultrasound, Retinal oximetry, arteriovenous difference, Carotid Stenosis
Received: 26 Mar 2025; Accepted: 10 Sep 2025.
Copyright: © 2025 Polidar, Pašková, Karhanová, Šín, Mudroch, Dorňák, Schreiberová, Divišová, Veverka, Franc, Hluštík, Šaňák and Král. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Petr Polidar, Palacký University, Olomouc, Olomouc, 771 47, Olomouc, Czechia
Michal Král, Palacký University, Olomouc, Olomouc, 771 47, Olomouc, Czechia
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