ORIGINAL RESEARCH article
Front. Neurol.
Sec. Sleep Disorders
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1601319
Sleep disorder is associated with increased risk of major adverse cardiovascular events in patients with schizophrenia
Provisionally accepted
- 1First Affiliated Hospital of Harbin Medical University, Harbin, China
- 2Harbin Red Cross Central Hospital, Harbin, Jilin Province, China
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Objective: To evaluate the association of sleep disorder with the risk of major adverse cardiovascular events (MACEs) among patients with schizophrenia-a population known to have heightened cardiometabolic vulnerability, yet underexplored in terms of sleep-related cardiovascular risk.: The cross-sectional study included 1,072 participants diagnosed with schizophrenia between January and December 2022. The sleep disorder was defined based on self-reported sleep duration, insomnia, and daytime sleepiness, and collected via self-completed questionnaire. Patients' MACEs including fatal and non-fatal myocardial infarction (MI), fatal and non-fatal stroke, and cardiovascular death were collected from chart review. Multivariate logistic regression model was employed to assess the association of sleep disorders with the risk of MACE after controlling for potential confounding factors.Results: Sleep disorders were common, with 25.7% reporting insomnia, 30.0% reporting short sleep duration (<6 hours), and 36.0% experiencing excessive daytime sleepiness. Among the 1,072 patients with schizophrenia, 20.3% experienced a MACE.Participants who have insomnia, short duration of sleep or excessive daytime sleepiness were more likely to have MACEs compared with those without these sleep disorders (all P<0.01). Multivariate logistic regression indicated that insomnia (OR=1.88, 95% CI: 1.26-2.78; P<0.01), short sleep duration (OR=1.66, 95% CI: 1.17-2. 35; P<0.01), and excessive daytime sleepiness (OR=1.55, 95% CI: 1.13-2.12; P<0.01) were significantly associated with the risk of MACE after controlling for potential confounding factors.Sleep disorders are significantly associated with a higher risk of MACEs in patients with schizophrenia.
Keywords: sleep disorder, sleep duration, insomnia, Daytime sleepiness, MACE, Schizophrenia
Received: 27 Mar 2025; Accepted: 09 Jul 2025.
Copyright: © 2025 Wu, Wang and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jinbo Wu, First Affiliated Hospital of Harbin Medical University, Harbin, China
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