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ORIGINAL RESEARCH article

Front. Neurol.

Sec. Applied Neuroimaging

Volume 16 - 2025 | doi: 10.3389/fneur.2025.1601459

This article is part of the Research TopicNew Insights in Neuroimaging: Highlights from the 42nd Annual Meeting of the Australasian Neuroscience Society (Perth, Western Australia)View all articles

Cognitive impairment and brain atrophy in patients with newly diagnosed aggressive lymphoma undergoing standard chemotherapy: a normative analysis

Provisionally accepted
Charlotte DitchfieldCharlotte Ditchfield1Priscilla GatesPriscilla Gates1,2,3Juan Dominguez DuqueJuan Dominguez Duque1Haryana Mary DhillonHaryana Mary Dhillon4Vincent DoreVincent Dore3,5Carlene WilsonCarlene Wilson6Karen CaeyenberghsKaren Caeyenberghs1*
  • 1Deakin University, Geelong, Australia
  • 2Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
  • 3Austin Health, Melbourne, Australia
  • 4The University of Sydney, Darlington, New South Wales, Australia
  • 5The Australian e-Health Research Centre, CSIRO Health & Biosecurity. melbourne, Melbourne, Australia
  • 6The University of Melbourne, Parkville, Victoria, Australia

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PG contributed all aspects of study design and collection of MRI data as part of her PhD study. She and was involved in development of research questions, methodology, data analysis and the overall preparation and writing of the manuscript. CD contributed to the literature reviews and study design, was involved in all aspects of data analysis and the overall preparation and writing of the manuscript. She undertook this research as part of her Honours thesis. KC was CD Honours primary supervisor and contributed to the original concept for this study and participated in all aspects of the design, research questions, methodology, data analysis, manuscript preparation and revision. JD contributed to study design and was involved in data analysis and the overall preparation and writing of the manuscript. HD, VD and CW contributed to study design and writing of the manuscript. All authors have been involved in preparing this manuscript and have read and approved the final version.

Keywords: cancer-related cognitive impairment, brain atrophy, Aggressive lymphoma, Normative analysis, chemotherapy

Received: 27 Mar 2025; Accepted: 08 Aug 2025.

Copyright: © 2025 Ditchfield, Gates, Dominguez Duque, Dhillon, Dore, Wilson and Caeyenberghs. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Karen Caeyenberghs, Deakin University, Geelong, Australia

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material