Cognitive impairment and brain atrophy in patients with newly diagnosed aggressive lymphoma undergoing standard chemotherapy: a normative analysis

Charlotte Ditchfield¹Priscilla Gates^1,2,3Juan Dominguez Duque¹Haryana Mary Dhillon⁴Vincent Dore^3,5Carlene Wilson⁶Karen Caeyenberghs^1*

• ¹Deakin University, Geelong, Australia
• ²Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
• ³Austin Health, Melbourne, Australia
• ⁴The University of Sydney, Darlington, New South Wales, Australia
• ⁵The Australian e-Health Research Centre, CSIRO Health & Biosecurity. melbourne, Melbourne, Australia
• ⁶The University of Melbourne, Parkville, Victoria, Australia

PG contributed all aspects of study design and collection of MRI data as part of her PhD study. She and was involved in development of research questions, methodology, data analysis and the overall preparation and writing of the manuscript. CD contributed to the literature reviews and study design, was involved in all aspects of data analysis and the overall preparation and writing of the manuscript. She undertook this research as part of her Honours thesis. KC was CD Honours primary supervisor and contributed to the original concept for this study and participated in all aspects of the design, research questions, methodology, data analysis, manuscript preparation and revision. JD contributed to study design and was involved in data analysis and the overall preparation and writing of the manuscript. HD, VD and CW contributed to study design and writing of the manuscript. All authors have been involved in preparing this manuscript and have read and approved the final version.