ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neuro-Ophthalmology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1603790
Correlation Analysis of Serum miRNA Expression Levels with the Degree of Macular Edema in Patients with Retinal Vein Occlusion and Its Clinical Implications
Provisionally accepted
- Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, China
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Objective: To investigate the correlation between serum microRNA (miRNA) levels and the degree of macular edema in retinal vein occlusion (RVO) patients. Methods: 180 RVO patients were divided into three groups based on macular edema severity: mild, moderate, and severe. Their serum miR-155-5p, miR-17-5p, and miR-375 levels were compared with 60 healthy controls. Pearson correlation analysis assessed the relationship between miRNA levels and clinical outcomes. Results: miR-155-5p levels were significantly higher in RVO groups compared to controls, while miR-17-5p and miR-375 levels were lower. Increased severity of macular edema correlated with higher miR-155-5p and lower miR-17-5p and miR-375 levels. After treatment, miR-155-5p levels decreased, while miR-17-5p, miR-375, and visual acuity improved. Correlation analysis showed that changes in miR-155-5p were negatively correlated with visual improvement and macular edema resolution, while miR-17-5p and miR-375 were positively correlated with these outcomes. Conclusion: Serum miR-155-5p, miR-17-5p, and miR-375 levels are associated with macular edema severity in RVO. These miRNAs may serve as biomarkers for disease progression and prognosis, aiding personalized treatment strategies.
Keywords: Serum miRNA, Retinal Vein Occlusion, Macular Edema, biomarkers, Correlation analysis
Received: 01 Apr 2025; Accepted: 09 Jul 2025.
Copyright: © 2025 Lin, Zhao, Zang and Bao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xin Bao, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, China
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