ORIGINAL RESEARCH article
Front. Neurol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1604540
Fatigue and Its Correlation with Anxiety and Depression in Patients with Multiple Sclerosis in China
Provisionally accepted
- 1Xianyang Hospital of Yan 'an University, Xianyang, China
- 2Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi Province, China
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Background: Multiple Sclerosis (MS) is a chronic, progressive, immune-mediated disease of the central nervous system. Fatigue is a common and disabling symptom in patients with MS (PwMS). Some psychological factors, such as depression, stress, and anxiety, also appear to be related to these issues.The study aimed to investigate the fatigue conditions of PwMS in China and its influencing factors, as well as to explore the correlation between fatigue with anxiety and depression. Methods: This study was a cross-sectional study conducted through the Internet, which collected demographic characteristics, clinical data, Modified Fatigue Impact Scale (MFIS), Beck Anxiety Inventory (BAI), and Beck Depression Inventory-II (BDI-II). Results: A total of 366 PwMS were included in this study. MFIS showed a median fatigue total score of 40.0(interquartile range [IQR] 26.0-52.0), with 55.7% (n=204) of patients experiencing fatigue. The scores on MFIS were positively correlated with age, disease duration, BAI score, and BDI-II score. Conclusion: The prevalence of fatigue among Chinese PwMS is 55.7%. Age, education, employment, marital status, type of disease, and disease duration are all factors influencing the fatigue rate in PwMS. Fatigue in PwMS exhibit strong positive correlations with depression and anxiety.
Keywords: Multiple Sclerosis, Epidemiology, Fatigue, Anxiety, Depression
Received: 02 Apr 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Wang, Wang, Zhao, Zhang, Zhang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guoxun Zhang, Xianyang Hospital of Yan 'an University, Xianyang, China
Xiongfei Zhao, Xianyang Hospital of Yan 'an University, Xianyang, China
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