SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Movement Disorders
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1609912
Treadmill Training for Gait Rehabilitation in Elderly Patients with Mild-to-Moderate Parkinson's Disease: A Systematic Review and Meta-Analysis
Provisionally accepted
- 1China-Japan Union Hospital, Jilin University, Changchun, China
- 2Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province, China
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Background: Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, leads to lower extremity dysfunction that critically contributes to falls and disability, yet effective rehabilitation remains limited. Objective: Systematic Assessment of the Effects of Treadmill Training on Lower Limb Motor Performance in Patients with PD Methods: As of March 1, 2024, a systematic search was conducted in PubMed, Web of Science, Embase, and the Cochrane Library to gather randomized controlled trials (RCTs) that report the effects of treadmill training on patients with PD. Data on the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III), the Timed Up and Go test (TUG), the Berg Balance Scale (BBS),6-Minute Walk Test (6MWT),10 Meter Walk Test (10MWT), and the Parkinson's Disease Questionnaire-39 (PDQ-39)outcome metrics, as well as general characteristics of the studies, participant demographics, and details regarding the intervention and control groups, were extracted. The Cochrane Risk of Bias tool was employed to evaluate the quality of articles at risk, while the funnel plot and Egger's test were utilized to assess publication bias.Results: 16 RCTs comprising 582 participants were included. The meta-analysis indicated that treadmill training (TT) produced significantly better outcomes than conventional therapy (CT) in the post-intervention assessments of motor symptoms (UPDRS-III: SMD: -0.45; 95% CI: -0.73 to -0.17), and gait performance (6MWT:
Keywords: Parkinson's disease, Treadmill training, Lower Extremity Function, Gait rehabilitation, elderly patients, Meta-analysis
Received: 11 Apr 2025; Accepted: 16 May 2025.
Copyright: © 2025 Yin, Peng, Zhang, Hu, Wei and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: PinMei Li, China-Japan Union Hospital, Jilin University, Changchun, China
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