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SYSTEMATIC REVIEW article

Front. Neurol.

Sec. Stroke

Volume 16 - 2025 | doi: 10.3389/fneur.2025.1614586

This article is part of the Research TopicRedefining Stroke Recovery: Current Trends and Recent AdvancesView all 7 articles

Efficacy and safety of repetitive transcranial magnetic therapy for post-stroke aphasia: a systematic review and meta-analysis of randomized controlled trials

Provisionally accepted
  • 1Ganzhou People's Hospital, Ganzhou, China
  • 2Gannan Medical University, Ganzhou, Jiangxi Province, China
  • 3Jiangxi Provincial People's Hospital, Nanchang, Jiangxi Province, China

The final, formatted version of the article will be published soon.

Objective: The purpose of this meta-analysis was to investigate the effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) in the treatment of patients with post-stroke aphasia (PSA). Methods: The PubMed, PEDro, Embase, Cochrane Library, CNKI, Wanfang Data and Web of Science databases were systematically searched from inception until January 30, 2024. Eligible randomized controlled trials (RCTs) contained information on the population (PSA), intervention (rTMS), and outcomes (Western Aphasia Battery, Aphasia Quotient, Aphasia Battery in Chinese, Boston Diagnostic Aphasia Examination, Aachener Aphasie Test, Concise Chinese Aphasia Test and Computerized Picture Naming Test). Participants in the rTMS intervention group were compared with those in sham or other control groups. Two independent researchers searched for, screened, and qualified the articles. Two independent researchers extracted key information from each eligible study. The authors' names, year of publication, setting, total sample size, rTMS parameters, baseline/mean difference (MD), and 95% confidence interval (CI) were extracted using a standardized form, and the methodological quality was assessed using the Cochrane Risk of Bias tool (Revman 5.40, Nordic Cochrane Center) and GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) system. Results: 30 relevant RCTs were included, involving a total of 1597 patients. The analysis turned out that rTMS combined with speech and language therapy (SLT) resulted in significant improvements in auditory comprehension, naming, repetition, and spontaneous speech in patients with PSA compared with sham stimulation combined with SLT or SLT alone in the control group. (auditory comprehension, MD=1.94, 95%CI=[1.16, 2.17], P<0.001; naming, MD=1.53, 95%CI=[0.82, 2.24], P<0.001; repetition, MD=1.79, 95%CI=[1.20, 2.38], P<0.001; spontaneous speech, MD=1.97, 95%CI=[1.65, 2.29], P<0.001). Conclusions: This meta-analysis showed that rTMS can safely and effectively promote the recovery of speech function in patients with PSA.

Keywords: repetitive transcranial magnetic stimulation, Post-stroke aphasia, Systematic review, noninvasive brain stimulation, Meta-analysis

Received: 19 Apr 2025; Accepted: 15 Sep 2025.

Copyright: © 2025 Dong, Xie, Diao, Gong, Huang and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Zhenying Dong, x7u03k@163.com

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