ORIGINAL RESEARCH article
Front. Neurol.
Sec. Applied Neuroimaging
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1614935
Altered brain network centrality in patients with cervical spondylotic myelopathy: Insights from resting-state fMRI
Provisionally accepted
- Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, China
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Objective To investigate the characteristics of brain network centrality in patients with cervical spondylotic myelopathy (CSM) by using degree centrality (DC) based on resting-state functional magnetic resonance imaging.We recruited 20 patients with CSM, along with 20 healthy controls(HC) who were matched in terms of age, gender, and educational background. The DC method was utilized to evaluate the changed spontaneous brain activities. The relationships between the DC values of different brain regions and the clinical features were analyzed by means of Pearson correlation analysis. Results Compared with HC, CSM group showed decreased DC values in the left medial frontal gyrus, middle temporal gyrus and angular gyrus, and increased DC values were found in the left middle occipital gyrus, right supplementary motor area (P<0.05). There was no significant correlation between DC values of abnormal region and clinical function score of CSM patients (P>0.05). Conclusion CSM patients have abnormal DC distribution in the whole-brain functional networks, which might be related to cortical reorganization after chronic spinal cord injury.
Keywords: Cervical spondylotic myelopathy, resting-state functional magnetic resonance imaging, Degree centrality, spinal cord injury, cortical reorganization
Received: 22 Apr 2025; Accepted: 31 Jul 2025.
Copyright: © 2025 Wu, Zheng, Jiang, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiang Wang, Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, China
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