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ORIGINAL RESEARCH article

Front. Neurol.

Sec. Neurotrauma

Volume 16 - 2025 | doi: 10.3389/fneur.2025.1618586

Impact of Serum Sodium Trajectory on 30-Day Mortality in Traumatic Brain Injury Patients: Insights from a Retrospective Cohort Study Using MIMIC-IV Database

Provisionally accepted
Shuangshuang  HuangShuangshuang Huang1Songmin  HuangSongmin Huang2Wulei  WangWulei Wang1Zhimin  LiZhimin Li1Yingjun  LiuYingjun Liu3*
  • 1Ningbo Haishu Traditional Chinese Medicine Hospital, Ningbo, China
  • 2Xiangshan County Traditional Chinese Medicine Hospital, Xiangshan, China
  • 3Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

The final, formatted version of the article will be published soon.

Background Hypernatremia is frequently encountered in individuals with traumatic brain injury (TBI), and research has demonstrated a correlation between serum sodium levels and patient outcomes in TBI cases. This study aims to explore the temporal patterns of serum sodium concentrations and assesses their prognostic significance in TBI patients. Methods This study employed data sourced from the database of Medical Information Mart for Intensive Care IV (MIMIC-IV). We applied a latent growth mixture model (LGMM) to construct the serum sodium trajectories of TBI patients within the first 96 hours of their intensive care unit (ICU) stay, based on mean serum sodium measurements taken at 24-hour intervals. Subsequently, Cox regression models were employed to analyze the associations among initial serum sodium levels, serum sodium trajectories, and mortality outcomes of 30 and 90 day.Results A total of 852 TBI patients were included, and the LGMM model categorized serum sodium trajectories into 4 classes. Significant differences in prognosis were observed between the different grades of TBI patients, with the worst prognosis for patients with TBI in Class 2 (slow-growth type) compared to Class 1 (normal stable type) and no significant difference in mortality for the remaining grades. In addition, after adjusting for confounding factors, high first serum sodium levels were related to higher 30-day (HR=2.14, 95% CI:1.13-4.04, P=0.019) and 90-day (HR=2.22, 95% CI:1.21-4.08, P=0.01) mortality rates in TBI patients.Both first-time serum sodium and serum sodium trajectory were independent influences on the prognosis of TBI patients. Thus, clinicians should closely monitor serum sodium in TBI patients and adjust treatment strategies based on its dynamic changes.

Keywords: Traumatic Brain Injury, Sodium, trajectory, Latent growth mixture model, MIMIC-IV database

Received: 26 Apr 2025; Accepted: 09 Jul 2025.

Copyright: © 2025 Huang, Huang, Wang, Li and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Yingjun Liu, Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

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