Distinct cerebral cortical microstructural changes in idiopathic normal-pressure hydrocephalus

Myong Hun Hahm¹Shin Young Jeong²Suhyun Kim³Sang-Woo Lee²Ki-Su Park²Eunhee Park²Mi-Yeon Eun²Uicheul Yoon³Kyunghun Kang^2*

• ¹Daekyung Imaging Center, Daegu, Republic of Korea
• ²Kyungpook National University, Daegu, North Gyeongsang, Republic of Korea
• ³Catholic University of Daegu, Gyeongsan, North Gyeongsang, Republic of Korea

Objective: The aims of the study were to investigate differences in cortical mean diffusivity (MD) among idiopathic normal-pressure hydrocephalus (INPH) patients, Alzheimer's disease (AD) patients, and healthy controls, and to analyze mean MD among INPH and AD groups in INPHspecific areas showing distinctive cortical MD changes for distinguishing INPH from AD. Methods: Forty-two INPH patients, 51 AD patients, and 23 healthy controls were imaged with MRI, including diffusion tensor imaging MR images, for surface-based analysis across the entire brain. Results: Compared with healthy controls, INPH patients showed a statistically significant reduction in MD in the high convexity of the frontal, parietal, and occipital cortical regions. We designate these clusters of lower MD as INPH MD LOW ROI. Additionally, a significant increase in MD, mainly in the ventromedial frontal cortex, ventrolateral frontal cortex, supramarginal gyrus, and temporal cortical regions, was observed in the INPH group relative to the control group. We designate these clusters of higher MD as INPH MD HIGH ROI. INPH patients showed significantly lower mean MD in INPH MD LOW ROI and higher mean MD in INPH MD HIGH ROI than AD. The mean MD of INPH MD LOW ROI had an AUC of 0.857 for differentiating INPH from AD. Conclusion: A distinctive pattern of cortical MD changes was found in INPH patients, and cortical regions of low MD distinguished INPH from AD with good diagnostic sensitivity and specificity. Our findings suggest microstructural changes in cortical integrity can help differentiate INPH and AD in elderly patients.