ORIGINAL RESEARCH article
Front. Neurol.
Sec. Cognitive and Behavioral Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1619083
The relationship between protein-energy wasting and cognitive impairment in patients receiving maintenance hemodialysis
Provisionally accepted
- Daping Hospital, Chongqing, China
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Objectives To investigate the relationship between protein-energy wasting (PEW) and cognitive impairment (CI) in patients undergoing maintenance hemodialysis (MHD).A total of 185 patients undergoing MHD between June 2020 and April 2022 were initially recruited. Among the initially recruited patients, 25 patients were excluded, and 160 patients were finally involved in this study. The Montreal Cognitive Assessment-Basic (MoCA-B) was utilized to assess patients' cognitive functions. Patients were categorized into two groups based on the presence or absence of PEW as per the diagnostic criteria. The severity of PEW was evaluated using the Scored Patient-Generated Subjective Global Assessment (PG-SGA) and Malnutrition Inflammation Score (MIS). Baseline data, PEW-related indicators, and cognitive function scores were compared between the CI and non-CI groups. Logistic regression analysis was employed to identify the factors influencing CI in patients undergoing MHD. Results There were significant differences between the two groups in terms of age, educational level, Kt/V, PEW detection rate, PEW-related indicators (albumin (ALB)), lean body mass, arm muscle circumference (AMC)), normalized dietary protein intake (nDPI), PG-SGA score, and MIS score (P<0.05). The MoCA-B scores of MHD patients with PEW were significantly lower than those of patients without PEW (P<0.05). The two groups exhibited significant differences in executive function, orientation, abstraction, delayed recall, and attention scores (P<0.05). Multivariate logistic regression analysis indicated that age, PEW severity, Kt/V, and ALB were significant influential factors of CI in patients undergoing MHD (P<0.05). 4 Conclusion PEW was closely associated with CI in patients undergoing MHD. Those combined with PEW were more likely to develop CI, and to suffer from more severe CI. Active precautionary measures should be taken against PEW to delay the progression of CI in patients undergoing MHD.
Keywords: cognitive impairment, Protein-energy wasting, Maintenance hemodialysis, relationship, Patients
Received: 27 Apr 2025; Accepted: 25 Jun 2025.
Copyright: © 2025 Liu, Fu, Chen, Chen, Zhang, Wan, Lin, Xiang, Li and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jun Liu, Daping Hospital, Chongqing, China
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