SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Movement Disorders
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1619236
Appendectomy and Risk of Parkinson's Disease: A Systematic Review and Meta-analysis
Provisionally accepted
- 1University of Chicago Medicine, Chicago, United States
- 2Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Beijing, China
- 3Huashan Hospital, Fudan University, Shanghai, Shanghai Municipality, China
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Braak's hypothesis suggests that α-synuclein may enter the central nervous system through the enteric nervous system and contribute to the pathogenesis of Parkinson's disease (PD).The appendix, enriched in α-synuclein, has been proposed as a possible entry point in PD pathogenesis. This systematic review and meta-analysis aimed to assess the association between appendectomy and PD risk using newly available data.Methods A literature search was conducted in PubMed and Embase through September 10, 2024, to identify studies on appendectomy and PD risk. Two independent reviewers screened and assessed articles for eligibility with a third reviewer involved in cases of disagreement. Study quality was assessed using the Newcastle-Ottawa Scale. Data for meta-analysis were pooled using a randomeffects model and analyzed in Review Manager 5.4. Meta-regression, subgroup, and sensitivity analyses were performed.Nine studies met inclusion criteria. Meta-analysis indicated no significant association between appendectomy and PD risk (RR: 1.01, 95% CI: 0.90-1.12, p=0.89). Subgroup analyses showed similar findings. Sensitivity analyses did not change the estimate.This analysis suggests no association between appendectomy and PD risk.
Keywords: Parkinson's disease, Parkinson, Appendectomy, Systematic review, Meta-analysis
Received: 27 Apr 2025; Accepted: 01 Jul 2025.
Copyright: © 2025 Chin, Tsang and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hok Leong Chin, University of Chicago Medicine, Chicago, United States
Haojun Shi, Huashan Hospital, Fudan University, Shanghai, Shanghai Municipality, China
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