ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1619440
This article is part of the Research TopicAdvances of lipid metabolism in neurological diseases and mental disordersView all 10 articles
The relationship between lipids level and cerebral microbleeds in patients with spontaneous intracerebral hemorrhage
Provisionally accepted
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University,, Beijing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Previous studies indicate a potential link between elevated serum lipid levels and an increased risk of cerebral microbleeds (CMBs). Since multiple CMBs can elevate the risk of future intracerebral hemorrhage (ICH), it is important to explore the relationship between lipid profiles and CMBs in ICH patients. However, data on this specific correlation in ICH populations are currently limited. Method: This study retrospectively enrolled 223 consecutive patients from a spontaneous ICH cohort. We collected comprehensive clinical, demographic, and laboratory data, with a focus on lipid levels and the presence of CMBs. Using a multivariate logistic regression model, we investigated the association between lipid parameters and CMB occurrence.Results: Among the 223 patients, 111 (49.8%) had CMBs. Univariate analysis showed that individuals without lobar CMBs tended to have higher levels of serum total cholesterol (TC), low-density lipoprotein (LDL), and non-high-density lipoprotein (Non-HDL). After adjusting for potential confounders, TC (odds ratio [OR], 0.989; 95% confidence interval [CI], 0.979-0.999; p=0.028) and Non-HDL (OR, 0.989; 95% CI, 0.979-1.000; p=0.043) were identified as independent predictors of lobar CMBs. Conclusion: Our findings suggest an inverse correlation between TC and Non-HDL levels and the presence of lobar CMBs in ICH patients. Further prospective studies are needed to clarify the causal relationship between statin use and CMBs in ICH patients and to evaluate the prognostic significance of CMB presence and severity in statin-treated individuals.
Keywords: Spontaneous, intracerebral hemorrhage, Total cholesterol, Non-high-density lipoprotein, cerebral microbleeds
Received: 03 Jun 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Feng, Wang, Wang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xingquan Zhao, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University,, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.