ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neuromuscular Disorders and Peripheral Neuropathies
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1619851
Retrospective analysis of the clinical effect of spinal cord stimulation in the treatment of painful diabetic peripheral neuropathy
Provisionally accepted
- 1Xingtai Ninth Hospital, Xingtai, China
- 2The Second Hospital of Hebei Medical University, Shijiazhuang, China
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The aim of this study was to evaluate the clinical outcomes of spinal cord stimulation (SCS) in patients with painful diabetic peripheral neuropathy (PDPN).Material and Methods: Ninety-two patients underwent permanent SCS implantation and completed a 6-month post-operative follow-up. The primary endpoint was patient amputation rate, and secondary endpoints included Quality of Life (QOL LC V2.0) scale, pain visual analogue scale (VAS), limb nerve conduction velocity, latency and amplitude, and vibration perception threshold (VPT).In patients with diabetic peripheral neuropathy, QOL LC V2.0 and VAS scores were significantly improved at 6 months postoperatively compared to preoperatively (24.74%, P < 0.05; 71.87%, P < 0.05). Compared with the median and ulnar nerves of the upper extremity peripheral nerves, the conduction velocities of the common peroneal, sural, superficial peroneal and tibial nerves of the lower extremity peripheral nerves were increased (P < 0.05), the latency was significantly shortened (P < 0.05) and the amplitude was significantly increased (P < 0.05) at 6 months after surgery. Compared to the dorsum of the hand, VPTs were significantly lower in the first toe and dorsum of the foot at 6 months postoperatively compared to preoperatively (P < 0.05). The overall amputation rate was 8.69%, with 3.26% for major amputation (above the ankle) and 5.43% for minor amputation (below the ankle).diabetic peripheral neuropathy, repair lower limb peripheral nerves, improve patients' quality of life, and reduce amputation rate.
Keywords: Diabetic peripheral neuropathy, Spinal Cord Stimulation, Lower Limb Pain, Neuromodulation, painful diabetic peripheral neuropathy
Received: 28 Apr 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Cui, Yang, Qiao, Gong, Hu, Ma, Wu and Huo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guitong Huo, Xingtai Ninth Hospital, Xingtai, China
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