SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1624101
This article is part of the Research TopicBrain Cytoprotection for Reperfusion Injury after Acute Ischemic StrokeView all articles
Global Collaboration and Innovation in Malignant Cerebral Edema Research: A Bibliometric Perspective
Provisionally accepted
- 1Nantong University, Nantong, China
- 2QIdong People's Hospital, Nantong, China
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Malignant cerebral edema (MCE) is a life-threatening complication of acute brain injuries, with mortality rates exceeding 80% in the absence of treatment. Despite advancements in osmotic therapies and decompressive craniectomy (DC), MCE continues to pose substantial clinical challenges. This study systematically maps the evolution of MCE research (2005MCE research ( -2024) ) to identify key trends, research gaps, and future priorities.A bibliometric analysis of 1,460 peer-reviewed articles from the Web of Science Core Collection was conducted using CiteSpace, VOSviewer, and Bibliometrix. Key metrics included publication trends, geographic and institutional contributions, keyword co-occurrence, citation networks, and co-authorship patterns.
Keywords: Malignant cerebral edema, Decompressive Craniectomy, cytotoxic edema, bloodbrain barrier, neurocritical care, bibliometric analysis, precision medicine, global collaboration
Received: 07 May 2025; Accepted: 09 Jul 2025.
Copyright: © 2025 Peng, Zhu, Zhang, Ji, Lv and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chuanguo Lv, QIdong People's Hospital, Nantong, China
Feng Feng, Nantong University, Nantong, China
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