ORIGINAL RESEARCH article
Front. Neurol.
Sec. Endovascular and Interventional Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1625856
Prognostic relevance of the triglyceride-glucose index in patients after thrombectomy for acute anterior circulation occlusion
Provisionally accepted
- 1Bethune First Hospital of Jilin University, Changchun, China
- 2Zhejiang Provincial People’s Hospital, Hangzhou, China
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Background: We aimed to investigate the relationship between the triglyceride-glucose (TyG) index and the 3-month prognosis after mechanical thrombectomy (MT) in patients with acute large-vessel occlusion in the anterior circulation. Methods: We performed a retrospective analysis of data collected from 320 patients who underwent MT at our institution between May 2022 and January 2024. The main outcome measure was the modified Rankin Scale (mRS) score, with a score of ≤ 2 at 90 days post-treatment indicating a good prognosis. Secondary outcomes were the 90day mRS score distribution, 24-hour postoperative National Institutes of Health Stroke Scale (NIHSS) score, and NIHSS score at discharge. Safety outcomes were 90-day mortality, intracranial hemorrhage (symptomatic and asymptomatic), and surgical complications. Results: One hundred and eight patients (33.8%) achieved functional independence at 90 days. After adjusting for covariates, patients who fell within the second group of the TyG index exhibited a lower probability of functional independence than those in the first group (adjusted odds ratio [aOR] = 0.450; 95% confidence interval [CI], 0.257-0.789; P = 0.005). Additionally, an increase of one unit in the TyG index was significantly correlated with a 33% reduction in the likelihood of achieving functional independence at 90 days postoperatively (aOR = 0.669; 95% CI: 0.450-0.996; P = 0.048). with higher TyG may indicate a poor prognosis. How this study might affect research, practice or policy The findings of this study present novel avenues for future research endeavors. Specifically, doctor should prioritize patients exhibiting elevated TyG indices, employing more aggressive therapeutic interventions and implementing rigorous monitoring protocols. Additionally, further investigation is warranted into the interplay between the TyG index and other biomarkers, as well as their combined influence on stroke prognosis, with the ultimate goal of enhancing patient outcomes.
Keywords: Intravascular treatment, Mechanical thrombectomy, ischemic stroke (acute), Large vessel occlusion, Triglyceride-glucose (TyG) index
Received: 12 May 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Wang, Wang, Li, Song, Wu, Jiang, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shouchun Wang, Bethune First Hospital of Jilin University, Changchun, China
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