ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1626196
This article is part of the Research TopicBrain Cytoprotection for Reperfusion Injury after Acute Ischemic StrokeView all 5 articles
The predictive value of triglyceride-glucose index on early neurological functional improvement in non-diabetic patients with acute ischemic stroke undergoing intravenous thrombolysis
Provisionally accepted
- Affiliated Central Hospital of Dalian University of Technology, Dalian, China
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Objective: To explore the predictive role of the triglyceride-glucose index (TyG index) on the early neurological improvement in non-diabetic patients with acute ischemic stroke (AIS) undergoing alteplase intravenous thrombolysis (IV-rtPA). Methods: This study included 490 AIS patients without diabetes, whose time from onset to hospital time ≤3 hours undergoing IV-rtPA in the Stroke Center of our hospital from September 2023 to September 2024 through the Stroke Emergency Map Management Platform in Dalian City. According to the National Institutes of Health Stroke Scale (NIHSS) score at 24 hours after IVT, the patients were divided into early neurological improvement (ENI) group (n=332) and non-ENI group (n=158). General information, risk factors, experimental data and the location of cerebral infarction were collected. Intergroup analyses were conducted using univariate or multivariate logistic regression. Results: (1) In the ENI group, blood glucose(FBG), triglycerides (TG), TyG index, and baseline NIHSS score were significantly lower than those in the non-ENI group (P < 0.05). (2) Binary logistic regression analysis indicated that a TyG index ≤7.15 and a low baseline NIHSS score could predict early neurological improvement undergoing intravenous thrombolysis (IVT) in AIS patients. The area under the curve (AUC) values for the TyG index, baseline NIHSS score, and the combined variable (Y) in predicting ENI were 0.640, 0.641, and 0.721, respectively, with the combined variable (Y) exhibiting the highest AUC value. Conclusion: The TyG index, baseline NIHSS score, and the combined variable (Y) are predictors of early neurological improvement, with the combined variable (Y) exhibiting a higher predictive efficiency.
Keywords: Acute ischemic stroke, intravenous thrombolysis, Early neurological improvement, Triglyceride-glucose index, Non-diabetic patients
Received: 03 Jun 2025; Accepted: 02 Sep 2025.
Copyright: © 2025 Li, Sui, Pan, Li, Gao, Shi, Zhao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hong ling Zhao, Affiliated Central Hospital of Dalian University of Technology, Dalian, China
Dong Chen, Affiliated Central Hospital of Dalian University of Technology, Dalian, China
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