REVIEW article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1627172
This article is part of the Research TopicRedefining Stroke Recovery: Current Trends and Recent AdvancesView all 6 articles
Research Progress on the Correlation Between Biological 1 Rhythms and the Blood-Brain Barrier After Ischemic Stroke
Provisionally accepted
Yuanchen Liao1
lei luo1Qiang Ma1,2Xiaofeng Gao3Yao Chen3Siyang Yan3Menghao He1Lijuan Liu3*
Desheng Zhou3*- 1Hunan University of Chinese Medicine, Changsha, China
- 2The Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, changsha, China
- 3The First Affiliated Hospital of Hunan University of Chinese Medicine, changsha, China
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Biological rhythms play a critical role in regulating human physiology and have been 22 implicated in the onset, progression, and recovery of ischemic stroke (IS). This review 23 summarizes recent experimental and clinical studies that associate circadian 24 regulation with post-stroke blood–brain barrier (BBB) repair, focusing on the role of 25 molecular clock components. Core clock components, including BMAL1 and 26 CLOCK, influence BBB integrity by regulating tight junction protein expression, 27 angiogenesis, neuroimmune responses, and neuroendocrine signaling. Finally, we 28 discuss emerging chronotherapeutic strategies that integrate circadian biology into 29 stroke rehabilitation.
Keywords: Biological rhythms1, ischemic stroke2, Blood-Brain Barrier3, angiogenesis4, Immune System5, Neuroendocrine system6
Received: 12 May 2025; Accepted: 12 Sep 2025.
Copyright: © 2025 Liao, luo, Ma, Gao, Chen, Yan, He, Liu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lijuan Liu, The First Affiliated Hospital of Hunan University of Chinese Medicine, changsha, China
Desheng Zhou, The First Affiliated Hospital of Hunan University of Chinese Medicine, changsha, China
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