ORIGINAL RESEARCH article
Front. Neurol.
Sec. Endovascular and Interventional Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1628374
Analysis of Risk Factors for Poor Prognosis After Endovascular Treatment of Tandem Lesions in Acute Ischemic Stroke
Provisionally accepted
- 1The Jiangyin Clinical College of Xuzhou Medical University, Xuzhou, China
- 2Jiangyin People's Hospital, Jiangsu, China
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Aims/background In China, the incidence of acute ischemic stroke (AIS) has been rising annually, accounting for 60%-70% of all stroke cases. To explore the risk factors leading to poor prognosis after endovascular treatment in patients with acute ischemic stroke tandem lesions after endovascular treatment.Methods A retrospective analysis was conducted on the clinical data of patients with tandem lesions who underwent endovascular therapy at Jiangyin People's Hospital affiliated with Xuzhou Medical University, from July 2018 to AugustPost-treatment revascularization was assessed using the modified Thrombolysis in Cerebral Infarction (mTICI) grading system, with grades 3 and 2bindicating good recanalization and grades 2a and below indicating poor recanalization.Patient prognosis at 90 days post-procedure was evaluated using the modified Rankin Scale (mRS), with scores of 0-2 classified as good prognosis and 3-6 as poor prognosis. The age, admission National Institutes of Health Stroke Scale score (NIHSS), gender, hypertension, diabetes mellitus, coronary artery disease, smoking, atrial fibrillation, carotid artery stenting, revascularization, site of tandem lesion (anterior or posterior circulation), and onset-recanalization time (minutes) of the enrolled patients were subjected to univariate analysis. Univariate analysis was performed, followed by multivariate logistic regression for variables with p < 0.1.Results A total of 75 patients were included, of whom 32 had good 90-day outcomes and 43 had poor outcomes. Compared to the good outcome group, patients with poor outcomes were older, had higher NIHSS scores at admission, and were less likely to achieve good recanalization (all p < 0.05). Multivariate analysis identified older age,
Keywords: Tandem lesions, Endovascular Procedures, prognosis, Mechanical thrombectomy, Acute ischemic stroke
Received: 15 May 2025; Accepted: 21 Aug 2025.
Copyright: © 2025 Zhang, Zhou, Cao and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yifan Zhang, The Jiangyin Clinical College of Xuzhou Medical University, Xuzhou, China
Xinmin Zhou, Jiangyin People's Hospital, Jiangsu, China
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