REVIEW article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1629461
This article is part of the Research TopicThe burden and impact of frailty in strokeView all 8 articles
Preexisting cognitive impairment in patients with acute stroke
Provisionally accepted
- 1Université Bourgogne Europe, Dijon, France
- 2CHU Dijon Bourgogne, Dijon, France
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Preexisting cognitive impairment is a significant but often overlooked factor in the management and outcome of stroke patients. Patients with prior cognitive impairment suffering a stroke have less access to stroke units, and less administration of acute revascularization therapies, as a possible consequence of limited research on the benefits of these treatments in this specific population, with most data coming from observational studies. Prestroke cognitive impairment is associated with a greater clinical severity at onset, increased complications, and poorer survival and functional outcome, with a reduced access to rehabilitation services, and a greater need for institutionalization. Patients with preexisting cognitive impairment have more prevalent comorbidities and frailty, which contribute to their increased vulnerability to adverse health outcomes. Further research is needed to better understand how these factors may influence clinical outcomes and decision-making in stroke care in patients with neurocognitive disorders. More inclusive clinical trials and standardized assessment strategies to guide optimal care for this vulnerable population are required. This will be crucial in adapting healthcare systems to meet the needs of a growing and aging population.
Keywords: Stroke, Dementia, cognitive impairment, Aging, Outcome, Frailty
Received: 15 May 2025; Accepted: 16 Oct 2025.
Copyright: © 2025 Kassir and Béjot. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yannick Béjot, yannick.bejot@chu-dijon.fr
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.