ORIGINAL RESEARCH article
Front. Neurol.
Sec. Cognitive and Behavioral Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1629576
Application of mindfulness-based stress reduction plan in post-stroke patients with mild depression
Provisionally accepted
- Jinhua Hospital of TCM, Zhejiang, China
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Abstract Objective To explore the therapeutic effect of mindfulness-based stress reduction in patients with post-stroke mild depression. Methods A total of 80 patients with mild depression after stroke received by our hospital from January 2023 to December 2023 were selected as the study subjects. Randomly divide the patients into two groups: 40 in the control group and 40 in the combination group. The control group received conventional intervention therapy, while the combination group was treated with a mindfulness-based stress reduction plan combined with conventional intervention therapy. Patients in both groups were treated for 8 weeks. The general information of patients in the two groups was statistically analyzed. Self-rating Depression Scale (SDS), Hamilton Depression Rating Scale (HAMD-17), Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA) scores and inflammatory factors (including TNF-α, hs-CRP, IL-6) expression levels were used to evaluate the efficacy of patients before and after treatment, and the total effective rate was counted for the two groups. Results After treatment, compared with that before treatment, the HAMD-17 and SDS scores and inflammatory factor levels of patients in the control group and combination group were significantly decreased (all p < 0.05), while the MMSE and MoCA scores of patients in the control group and combination group were significantly increased (all p < 0.05). However, after treatment, the HAMD-17 and SDS scores and inflammatory factor levels of patients in the combination group were significantly lower than those in the control group (all p < 0.05). The scores of MMSE and MoCA were significantly higher than those in the control group (p<0.05). Conclusion In the treatment of stroke patients with mild depression, mindfulness-based stress reduction combined with conventional intervention therapy can improve the overall response rate compared with conventional intervention therapy alone and has a significant advantage in reducing depression.
Keywords: Mindfulness-based stress reduction, Progressive resistance training, Stroke, Mild depression, Depression
Received: 16 May 2025; Accepted: 16 Sep 2025.
Copyright: © 2025 Pang, Qiu, He and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dong Qiu, 15058597295@163.com
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