SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Epilepsy
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1630581
The levels of miR-155 in epilepsy patients: A meta-analysis
Provisionally accepted
- 1Guangxi University of Chinese Medicine, Nanning, China
- 2Putian Hanjiang Hospital, Putian, China
- 3Department of Neurology, Guangxi Zhuang Autonomous Region Brain Hospital, Liuzhou, China
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Neuroinflammation plays an important role in the development and progression of epilepsy. It can be both a result and a potential cause of those seizures. MiR-155 plays a crucial role in inflammatory responses, and its expression is upregulated under various neuroinflammatory conditions. This study aims to compare the expression levels of miR-155 in the brain tissue or serum of epilepsy patients and healthy controls, assessing the correlation between miR-155 levels and epilepsy.The meta-analysis evaluates to assess and compare the levels of miR-155 in the brain tissue and serum of epilepsy patients and healthy controls.The databases PubMed, Embase, Cochrane Library, CNKI, VIP, and WanFang DATA were searched from inception until Dec 30, 2024 by two researchers. The relative expression level of miR-155 in the tissues or serum was the primary outcome of the search. After extracting data independently, the two researchers used the Cochrane Collaboration's tool for assessing risk of bias.All data were analyzed using Review Manager (V.5.4.1) statistical software.This meta-analysis (9 studies, 394 patients) reveals elevated miR-155 in epilepsy patients vs. controls (SMD=1.62, P=0.001), especially in brain tissue. Subgroups confirm consistency across ages/regions. Subgroup analysis revealed no significant differences by country (p = 0.31), age category (p = 0.63) and sample source (p = 0.15), indicating robust consistency of the primary findings. MiR-155 may serve as a neuroinflammatory biomarker in epilepsy.Compared to healthy controls, the relative expression level of miR-155 in the brain tissue or serum of epilepsy patients increased.
Keywords: Epilepsy, miR-155, Neuroinflammation, biomarker, Meta-analysis
Received: 14 Jun 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 WANG, CHEN, YA, CHEN, LU, LIU, WU, DIAO and LIU. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Limei DIAO, Department of Neurology, Guangxi Zhuang Autonomous Region Brain Hospital, Liuzhou, China
Huihua LIU, Department of Neurology, Guangxi Zhuang Autonomous Region Brain Hospital, Liuzhou, China
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