METHODS article
Front. Neurol.
Sec. Sleep Disorders
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1631296
A new objective titration procedure using remotely contactless intelligent sleep monitoring system for the treatment of mandibular advancement device in OSAHS patient
Provisionally accepted
- Beijing Jishuitan Hospital, Beijing, China
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Background: The key to treating Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) by mandibular advancement device (MAD) lies in determining the optimal mandibular advancement, but current subjective titration methods are time-consuming and have poor compliance. Therefore, this study proposes an objective titration scheme based on a Remotely Contactless Intelligent Sleep Monitoring System (RCISMS) to optimize the MAD titration process, improve treatment efficiency, and enhance patient comfort.Methods: This study enrolled 60 OSAHS patients, randomly divided into a RCISMS-guided titration group (n=30) and a subjective titration group (n=30). Patients in the RCISMS-guided titration group used RCISMS at home to monitor AHI, which was transmitted in real-time to clinicians online for remote guidance on MAD adjustments. The subjective titration group required adjustments based on patient self-reports during clinic visits. The primary endpoint was the reduction in AHI, and secondary endpoints included titration time efficiency and improvements in subjective symptoms (Epworth Sleepiness Scale, Snoring Scale).Results: Both RCISMS-guided and subjective titration significantly reduced AHI (by 73.7% and 69.0%, respectively), with no significant difference in final AHI levels between the two groups (p=0.0828). RCISMS-guided titration significantly shortened the titration cycle (27.00±2.12 days vs. 45.07±8.25 days, p<0.0001), saving 40.01% of the time compared to subjective titration. There were no significant differences between the two groups in ESS reduction (RCISMS group 3.0±1.2 vs. subjective titration group 3.3±1.5, p=0.3943) and Snoring VAS scores reduction (RCISMS group 3.8±0.5 vs. subjective titration group 3.9±0.5, p=0.3306).Conclusion: The RCISMS-guided MAD titration scheme can achieve the same therapeutic effect as traditional subjective titration methods in a shorter time, while reducing the number of patient visits, improving treatment convenience and compliance, and demonstrating significant potential for clinical application.
Keywords: Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS), Remotely Intelligent Sleep Monitoring System, Mandibular advancement device, Compliance, titration cycle
Received: 19 May 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Lei, Zhu, Yang, Lai and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huijia Lei, Beijing Jishuitan Hospital, Beijing, China
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