Evaluating the efficacy of machine learning in predicting postherpetic neuralgia: A systematic review and meta-analysis

Zheng Lin^1*Hongfei Wang¹Chenxi Ma¹RUYI JU²Yi Cao^1*Ping Lin^2*

• ¹First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China
• ²Zhejiang Chinese Medical University, Hangzhou, China

The prediction of postherpetic neuralgia (PHN) is of great clinical significance. PHN prediction based on machine learning have received extensive attention in recent years. This study aims to conduct a comprehensive evaluation of machine learning in PHN prediction and provide guidance for the future models.The system retrieved the relevant literatures published in the PubMed, Web of Science, Embase and Cochrane Library databases from the establishment of the database to May 2025. Literature screening and data extraction were conducted in accordance with the PRISMA guidelines. According to the heterogeneity, the fixed-effect or the random-effect model was selected for data synthesis. The potential sources of heterogeneity were further explored through subgroup analysis, sensitivity tests and meta-regression. Funnel plots and Deeks' tests were used to evaluate the possible publication biases.The main meta-analysis included 41 models from 14 studies. The results showed that machine learning demonstrated excellent performance in predicting PHN (sensitivity: 0.81, 95% confidence interval (CI): 0.74-0.86; specificity: 0.84, 95% CI: 0.79-0.88; area under the curve: 0.90, 95% CI: 0.87-0.92). Meta-regression analysis indicates that the source of the data set, model selection, and the choice of predictors are the main reasons leading to heterogeneity. Subgroup analysis showed that the training set model outperformed the validation set model. Logistic regression and other machine learning had varying strengths and weaknesses. Serum data or omics analysis did not significantly enhance model performance.Machine learning represents a promising approach for the prediction of PHN. However, most of the existing models face issues like lack of external validation, overfitting, and insufficient reporting standardization. This has raised doubts about whether the current PHN prediction models can still maintain a high prediction accuracy when extended to external data. To improve future models, we recommend conducting strict external validation, clearly reporting cutoff values (balanced, positive, and negative), and adhering to international predictive model reporting standards. When applicable, ensemble learning and pain trajectory analyses should also be considered.