BRIEF RESEARCH REPORT article
Front. Neurol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1634960
This article is part of the Research TopicNeuro-Immune Crosstalk in Peripheral Neuropathy: From Mechanisms to Therapeutic OpportunitiesView all 5 articles
Peripheral Neuromodulation in Spasticity-Plus Syndrome: Effects of Pulsed Radiofrequency on Tonic-Painful Disorders in Multiple Sclerosis
Provisionally accepted
Luigi Di Lorenzo*
Carmine D'Avanzo- Mediterranean Neurological Institute Neuromed (IRCCS), Pozzilli, Italy
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This manuscript fits squarely within the scope of Frontiers in Neurology -Multiple Sclerosis and Neuroimmunology, as it presents a clinically grounded case of Spasticity-Plus Syndrome (SPS) in a patient with secondary progressive multiple sclerosis (SPMS), highlighting the therapeutic role of peripheral neuromodulation. By addressing the pathophysiological underpinnings of SPS and demonstrating the effects of pulsed radiofrequency (PRF) on complex spastic and nociceptive symptoms, this report aligns with the journal's focus on novel translational strategies and multidisciplinary approaches for managing MS-related disability. The content contributes to the evolving understanding of integrated symptom management in MS and supports the inclusion of neuromodulatory techniques in personalized care.
Keywords: Carmine D'Avanzo: Conceptualization, Data curation, Software, Writingoriginal draft. Luigi Di Lorenzo: Investigation, methodology, Writingoriginal draft, Writingreview & editing spasticity plus syndrome, Neuromodulation
Received: 25 May 2025; Accepted: 27 Aug 2025.
Copyright: © 2025 Di Lorenzo and D'Avanzo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Luigi Di Lorenzo, Mediterranean Neurological Institute Neuromed (IRCCS), Pozzilli, Italy
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.