ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
Risk Factors for Cardiac Injury in Patients with Ischaemic Stroke: A Retrospective Analysis
Provisionally accepted
- 1Xuanwu Hospital, Capital Medical University, Beijing, China
- 2Peking Union Medical College Cancer Hospital, Chinese Academy of Medical Sciences, National Cancer Center, National Cancer Clinical Research Center, Beijing, China
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Objective: To identify independent risk factors for cardiac injury (CI) in patients with ischaemic stroke (IS) through a retrospective analysis, providing evidence for early screening and intervention strategies. Methods: A single-centre retrospective study was conducted among hospitalised patients with IS, who were classified into CI and non-CI groups. CI was defined as elevation of one or more cardiac biomarkers (cTnI/T, CK-MB, or BNP) above the upper reference limit, with concurrent ECG or echocardiographic abnormalities. Clinical characteristics, laboratory parameters, and prognostic variables were analysed using univariate methods (chi-square test, t-test, or Mann–Whitney U test), followed by multivariate logistic regression to identify independent risk factors. Odds ratios (ORs) and 95% confidence intervals were then calculated. Results: Across 393 patients with IS (100 with CI and 293 without CI), univariate analysis identified significant differences in multiple parameters, including age, vital signs, cardiac biomarkers (BNP, CK-MB, cardiac troponin I), inflammatory markers (hs-CRP, LDH), renal function (BUN, creatinine), coagulation markers (D-dimer), and comorbidities (atrial fibrillation, coronary heart disease, heart failure) between the groups (P < 0.05). However, after adjusting for these potential confounders in multivariate logistic regression analysis, neither Glasgow Coma Scale (GCS) scores nor blood urea nitrogen (BUN) levels remained statistically significant independent predictors of CI in patients with IS (P > 0.05). Conclusion: Although GCS scores and BUN levels may be associated with CI in patients with IS, a clear operational definition of CI is essential for diagnostic consistency and early risk identification. Enhanced screening and monitoring of high-risk patients, combined with clinical and biomarker evaluation, are essential for optimising early management strategies and improving outcomes.
Keywords: ischaemic stroke, Cardiac Injury, Reinfarction, Glasgow Coma Scale, Blood Urea Nitrogen
Received: 27 May 2025; Accepted: 05 Nov 2025.
Copyright: © 2025 Tang, Li, Liu, Gao, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui Tang, tanghui8866@163.com
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