ORIGINAL RESEARCH article
Front. Neurol.
Sec. Cognitive and Behavioral Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1637561
Unveiling the Predictive Synergy of Red Cell Distribution Width and Peak Morning Home Systolic Blood Pressure: A Dual Biomarker Approach for Cognitive Risk Stratification in Hypertensive Minor Stroke
Provisionally accepted
- People's Hospital Affiliated to Ningbo University, Ningbo, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Aim: This study aims to evaluate the predictive value of combining red cell distribution width (RDW) and peak morning home systolic blood pressure (SBP) for post-stroke cognitive impairment (PSCI) in hypertensive patients with minor stroke.: A prospective cohort study enrolled 430 patients, randomly stratified into training (n = 301) and validation (n = 129) cohorts. Multivariable logistic regression and random forest model were employed for analysis. Results: Both RDW and peak morning home SBP emerged as independent risk factors for PSCI (OR = 70.95 and 1.104, respectively; P < 0.001 for both). The combined model significantly improved predictive performance, achieving an area under the curve (AUC) of 0.925 (95% CI: 0.901-0.948), surpassing individual biomarkers (RDW: AUC = 0.883; peak morning home SBP: AUC = 0.765). Subgroup analyses demonstrated superior discriminative capacity in coronary heart disease (AUC = 0.956) and female patients (AUC = 0.925).The integration of RDW and peak morning home SBP provides an efficient, cost-effective, and clinically translatable tool for cognitive risk stratification in hypertensive patients with minor stroke, offering enhanced precision over conventional single-biomarker approaches.
Keywords: Red cell distribution width, Peak morning home systolic blood pressure, Hypertension, cognitive impairment, Minor stroke
Received: 29 May 2025; Accepted: 07 Aug 2025.
Copyright: © 2025 Shu, Chen, Song and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yimin Shu, People's Hospital Affiliated to Ningbo University, Ningbo, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.