BRIEF RESEARCH REPORT article
Front. Neurol.
Sec. Neuro-Otology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1638357
Association of low serum 25-hydroxyvitamin D levels with hearing loss severity in Menière Disease: A cross-sectional study
Provisionally accepted
- 1Ningbo No 2 Hospital, Ningbo, China
- 2Tiantai People’s Hospital of Zhejiang Province, Taizhou, China
- 3School of Medicine, Shaoxing University, Shaoxing, China
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Introduction: Growing evidence implicates vitamin D in inner ear homeostasis, though its association with Ménière's disease (MD) remains incompletely characterized. This study aimed to compare serum 25-hydroxyvitamin D (25(OH)D) levels between patients with MD and healthy controls and to assess its correlation with hearing thresholds in MD cohort. Methods: In this cross-sectional study, 49 patients with MD and 250 matched healthy controls were enrolled at our institution between January 2023 and January 2025. Groups were matched for demographics, comorbidities, exercise habits, and seasonal blood collection timing. Serum 25(OH)D levels and pure-tone audiometry (PTA) results were measured and analyzed. Results: Patients with MD exhibited significantly lower 25(OH)D levels than controls (18.4 ± 5.9 [45.9 ± 14.7 nmol/L] vs. 21.1 ± 6.2 ng/mL [52.7 ± 15.5 nmol/L]; P = 0.006). After adjusting for covariates, vitamin D deficiency was independently associated with MD (adjusted OR = 2.21; 95% CI: 1.13-4.32; P = 0.021). A moderate inverse correlation existed between 25(OH)D and PTA thresholds (ρ = -0.440, P = 0.002). Conclusion: Hypovitaminosis D is associated with MD and hearing loss severity, warranting further longitudinal studies to explore causality and therapeutic implications.
Keywords: Hearing Loss, Meniere Disease, Otolithic Membrane, Vitamin D, Vitamin D Deficiency
Received: 30 May 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Wu, Lai, Li, Han, Liu and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weinv Fan, Ningbo No 2 Hospital, Ningbo, China
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