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ORIGINAL RESEARCH article

Front. Neurol.

Sec. Movement Disorders

Volume 16 - 2025 | doi: 10.3389/fneur.2025.1640614

Inflammatory changes in early Dementia with Lewy bodies

Provisionally accepted
  • University of Alabama at Birmingham, Birmingham, United States

The final, formatted version of the article will be published soon.

Objective: To examine if immune cell changes are present in early stages of Dementia with Lewy Bodies (DLB). Background: Evidence for inflammation in synucleinopathies has been building. An extensive number of studies have documented inflammatory changes in Parkinson’s disease (PD), but much less is known about DLB. Post-mortem DLB brains show T-cell infiltration, and flow cytometry and cytokine/chemokine measures in DLB subjects have suggested the presence of inflammatory responses in DLB. However, there is limited understanding if immune cell changes are present at the earliest stages of DLB. Methods: We recruited a small, exploratory cohort of nine subjects with Mild Cognitive Impairment – Lewy Bodies (MCI-LB) as part of the broader Alabama Udall cohort study, which is focused on the role of inflammation in early PD. The MCI-LB cohort was compared to subjects with de novo PD (n=64) and healthy controls (n=70) from the larger Alabama Udall cohort. Subjects underwent clinical assessments, including Movement Disorder Society-United Parkinson’s Disease rating scale (MDS-UPDRS), and comprehensive cognitive assessment. Blood was obtained for flow cytometry and cytokine/chemokine analyses. Results: Demographics and medical history were comparable between groups. Significant differences in University of Pennsylvania Smell Identification Test, Schwab and England Activities of Daily Living, and MDS-UPDRS scores were observed between the groups. MCI-LB subjects had poorer cognitive composite scores compared to PD participants. MCI-LB subjects demonstrated a robust 60% reduction in mature neutrophils compared to healthy controls. Conclusions: Our data show changes in innate immune cells in MCI-LB compared to healthy controls in this small exploratory study. A larger cohort study is needed to validate these findings.

Keywords: Parkinson's disease, Dementia with Lewy bodies, Inflammation, Cognition, Neutrophils

Received: 03 Jun 2025; Accepted: 05 Aug 2025.

Copyright: © 2025 Yacoubian, Qin, Amara, Stover, Ruffrage, Zhang, Kennedy, Geldmacher, Gerstenecker, Standaert and Benveniste. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Talene Yacoubian, University of Alabama at Birmingham, Birmingham, United States

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