ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neuroepidemiology
Ethnic Disparities in Patients with Early-Onset Alzheimer's Disease (EOAD)
Provisionally accepted
- 1The University of Chicago, Chicago, United States
- 2Northwestern Memorial HealthCare, Chicago, United States
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INTRODUCTION: Ethnic disparities in Early-onset Alzheimer’s Disease (EOAD) have not been fully characterized. METHODS: We retrospectively identified 81 EOAD patients February 2017-February 2022. RESULTS: 53 (65.4%) identified as White and 28 (34.6%) identified as Black. Age at diagnosis (years) was (57.3 ± 5.24) in Black patients compared to (56.3 ± 4.96) in White patients. Time to diagnosis (years) was longer in Black patients (3.39 ± 1.85) compared with White patients (2.64 ± 1.75). Black patients had lower MOCA scores (12.17 ± 6.9) compared with White patients (14.9 ± 5.8). An amnestic profile was more common in Black patients (19 or 67.9%) than non-amnestic presentations (9 or 32.1%). Non-amnestic presentations were more common in White patients, with 9 (17%) patients with PCA, 8 (15%) with fAD and 8 (15%) with l-PPA. DISCUSSION: In our cohort, Black patients with EOAD are on average older, more advanced and experienced longer delays in diagnosis than their White counterparts.
Keywords: Early onset Alzheimer disease, African American, Black, healthcare delivery, socioeconomic disparities, Dementia
Received: 10 Jul 2025; Accepted: 27 Nov 2025.
Copyright: © 2025 Yang, Yoon, Taruc, Timpo, Mastrianni and Seibert. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kaitlin Seibert
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