ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1644817
This article is part of the Research TopicQuality of Stroke Care: What Could Be Improved, and How? - Volume IIView all 15 articles
Association between Pan-Immune Inflammatory Value (PIV) and all-cause mortality in critically ill patients with ischemic stroke: a retrospective analysis of the MIMIC-IV database (2008-2022)
Provisionally accepted
Anni ChenJiahui WangQiaoying Huang
Zhizhou HuDonglan JiangYunnan HuLiying PanJianhui Chen
XIAOHONG HU*- Longyan First Hospital, Longyan, China
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Systemic inflammation and immune responses are key contributors to the onset and progression of ischemic stroke, influencing both tissue damage and repair. This study investigates the association between the Pan-Immune Inflammatory Value (PIV)-a composite biomarker derived from routine blood tests-and all-cause mortality (ACM) in critically ill ischemic stroke patients.We extracted data from the MIMIC-IV (v3.0) database, identifying ischemic stroke patients using ICD-9/10 codes. PIV was calculated using the formula: (monocytes × neutrophils × platelets) ÷ lymphocytes. ACM was assessed during hospitalization and at 30-, 90-, and 365-days post-admission. Multivariable Cox proportional hazards models and restricted cubic spline (RCS) analyses were used to assess the relationship between PIV and mortality. Kaplan-Meier curves, time-dependent ROC curves, and decision curve analysis (DCA) evaluated survival differences and predictive performance. Subgroup and interaction analyses were conducted using likelihood ratio tests.A total of 1,365 critically ill ischemic stroke patients were included, with 50.48% male. Elevated PIV was significantly associated with higher mortality during hospitalization (HR: 1.98), and at 30-day (HR: 2.56), 90-day (HR: 1.97), and 365-day 4 (HR: 1.76) follow-ups (all P < 0.01). RCS analysis revealed a J-shaped relationship between PIV and ACM. Subgroup analyses showed consistent results without significant interaction effects.PIV is an independent predictor of short-and long-term mortality in critically ill ischemic stroke patients. These findings suggest PIV could serve as a practical and cost-effective biomarker for risk stratification and prognosis in clinical settings.
Keywords: cerebrovascular disease, All-cause mortality, MIMIC-IV, Inflammatory biomarker, Stroke
Received: 10 Jun 2025; Accepted: 30 Jul 2025.
Copyright: © 2025 Chen, Wang, Huang, Hu, Jiang, Hu, Pan, Chen and HU. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: XIAOHONG HU, Longyan First Hospital, Longyan, China
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