ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1644963
Association of systemic inflammatory response index with 1 acute ischemic stroke in young people
Provisionally accepted
He Wang
Huimin Qiao
Yi Yang*
Ya Wen*Xiangjian ZhangPeng WuYuxiao GaoXin LiuHaisen AnWanyue GeMeiling SongYatong Wang- Second Hospital of Hebei Medical University, Shijiazhuang, China
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Objective:To explore the correlation between Systemic Inflammatory 29 Response Index(SIRI)and acute ischemic stroke in youth. 30 Methods:A retrospective study was conducted to select 90 patients aged 18 31 -45 with acute ischemic stroke as the youth cerebral infarction(YCI)group 32 and 50 patients of the same age bracket with non-stroke and non-33 intracranial atherosclerosis hospitalized during the same period as the 34 control group.The clinical information,blood biochemical indicators and 35 imaging data of the subjects were analyzed.Binary logistic regression was 36 used to assess the independent association of SIRI with 37 YCI.Further subgroup analysis was performed in YCI patients.Subgroup 38 classification included:i)infarct volume grouping;ii)intracranial artery 39 stenosis grouping;iii)Trial of ORG 10172 in Acute Stroke 40 Treatment(TOAST) stroke classification grouping;iv)infarct distribution 41 grouping;v)vasculopathy grouping. 42 Results:The SIRI values were higher in the YCI group than in the control 43 group(P=0.005).After adjusting for confounders, multivariate logistic 44 regression confirmed SIRI as an independent factor associated with 45 YCI(OR=1.692,95%CI:1.045–2.739,P=0.032).The Receiver operating
Keywords: Inflammation, infarct volume, systemic inflammatory response index, Youth acute ischemic stroke, Intracranial artery stenosis
Received: 07 Jul 2025; Accepted: 21 Oct 2025.
Copyright: © 2025 Wang, Qiao, Yang, Wen, Zhang, Wu, Gao, Liu, An, Ge, Song and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yi Yang, vpnyx@hebmu.edu.cn
Ya Wen, wenya2046@hebmu.edu.cn
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