REVIEW article
Front. Neurol.
Sec. Experimental Therapeutics
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1645457
This article is part of the Research TopicMolecular and cellular mechanisms underpinning adaptation and recovery after spinal cord injuryView all articles
Exosome-Mediated Repair of Spinal Cord Injury: Cellular Sources, Mechanisms of Action, and Combined Therapeutic Strategies
Provisionally accepted
- 1The First People's Hospital of Yunnan Province, Kunming, China
- 2Kunming University of Science and Technology School of Medicine, Kunming, China
- 3Yunnan University, Kunming, China
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Abstract: Spinal cord injury (SCI) presents a significant clinical challenge due to its complex pathology and limited capacity for self-repair, often resulting in substantial physical dysfunction. Conventional treatments emphasize symptom management, yet usually fail to achieve nerve regeneration and full functional recovery. Recently, Exosomes(Exos) have gained attention as key modulators in biological processes such as immune regulation, intercellular communication, and tissue repair, showing promise in nerve injury and regeneration. This review synthesizes recent research on Exosome-based SCI therapies, including their biological origins, mechanisms, potential applications, and current limitations. Although Exos' research in SCI is nascent, early studies indicate promising safety and efficacy. Future studies are encouraged to delve deeper into Exos preparation, optimization, and delivery to maximize therapeutic effectiveness, potentially advancing SCI treatment options.
Keywords: spinal cord injury, Exosomes, Nerve repair, Immunoregulation, miRNA, NDDS
Received: 26 Jun 2025; Accepted: 28 Aug 2025.
Copyright: © 2025 Cha, Li, Pu, Zhang, Lu, Huang, Li and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoyang Lu, Yunnan University, Kunming, China
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