BRIEF RESEARCH REPORT article
Front. Neurol.
Sec. Neuro-Ophthalmology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1647079
This article is part of the Research TopicAdvances in Understanding Visual Disorders Linked to Cortical DysfunctionView all 8 articles
Visuospatial processing in patients with Alzheimer's disease and cerebral amyloid angiopathy
Provisionally accepted
- 1Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany
- 2Department of Diagnostic and Interventional Neuroradiology, University Hospital RWTH Aachen, Aachen, Germany
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There is a well-established but poorly understood pathological and clinical overlap between cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD). Some studies have suggested a posterior predominance of CAA-related lesions, but it remains unclear how well this can be captured by specific measures of low-to high-level visual cortical processing.We compared the characteristics of 30 patients with AD and/or CAA, grouped by impairment measures of low-to mid-level visual cortical processing, and explored associations with clinical characteristics, neurodegeneration biomarkers, CAA imaging features, and volumetric structural measures.Results: Twenty participants were classified as impaired on tasks of low-to midlevel visual cortical function. Impairment in these tasks was associated with performance on more complex visuoconstruction tasks, which in turn showed a correlation with structural integrity volume and cortical thickness in the occipital lobe. We found no association between impairment in low-to mid-level visual cortical functions or visuoconstruction tasks and specific measures of CAA or AD pathology.Discussion: Impairments in visuospatial functions, although reflecting structural damage in posterior brain regions, were not independently associated with markers of CAA or AD.
Keywords: visuospatial processing, visual cortical functions, Alzheimer's disease, Cerebral Amyloid Angiopathy, CSF biomarkers, neuropsychological assessment
Received: 14 Jun 2025; Accepted: 12 Aug 2025.
Copyright: © 2025 Costa, Albrecht, Ridwan, Reetz, Schulz and Pinho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ana Sofia Costa, Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany
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