ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1650795
Association between the C-reactive protein-albumin-lymphocyte (CALLY) index and mortality in Elderly Patients with Dysphagia Requiring Nutritional Support
Provisionally accepted
- 1Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, China
- 2Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- 3Beijing Pinggu Hospital, Beijing, China
- 4People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background While the novel C-reactive protein-albumin-lymphocyte (CALLY) index—integrating inflammatory, nutritional, and immune markers—has proven valuable for prognosis in various diseases, its utility in predicting outcomes for dysphagia patients is still unclear. Methods This retrospective cohort analysis utilized data sourced from the Dryad Digital Repository. The CALLY index (albumin × lymphocyte count/C-reactive protein ×10⁴) was calculated. After logarithmic transformation (Ln-CALLY), the patients were divided into low Ln-CALLY group (≤2.21) and high Ln-CALLY group (>2.21). All-cause mortality served as the primary endpoint. The association between Ln-CALLY and outcomes was evaluated using Kaplan-Meier analysis with log-rank testing and multivariable Cox proportional hazards regression. The dose-response relationship was evaluated by restricted cubic splines (RCS). Results This study enrolled 253 elderly dysphagia patients. Analysis revealed Ln-CALLY as a significant predictor of all-cause mortality. Conclusion The CALLY index shows promise as a predictor of mortality risk and long-term outcomes in older dysphagia patients.
Keywords: CALLY index, dysphagia, Percutaneous endoscopic gastrostomy, Total parenteralnutrition, prognosis
Received: 20 Jun 2025; Accepted: 10 Sep 2025.
Copyright: © 2025 Shen, Jin, Mei, Guan, Yan and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Aihua Liu, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.