ORIGINAL RESEARCH article
Front. Neurol.
Sec. Artificial Intelligence in Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1652157
This article is part of the Research TopicArtificial Intelligence and Machine Learning approaches for Survival Analysis in Neurological and Neurodegenerative diseasesView all 4 articles
Study on the Prediction of Short-Term Clinical changes After Cerebral Infarction Using Carotid Plaque Ultrasound Strain Elastography
Provisionally accepted
- 1Beijing Chaoyang Hospital Affiliated to Capital Medical University Department of Ultrasound Medicine, Beijing, China
- 2Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Objective: To evaluate the value of ultrasound strain elastography in assessing carotid plaque stiffness for predicting short-term clinical changes after cerebral infarction. Methods: Patients with cerebral infarction and carotid atherosclerotic plaque identified through routine ultrasound examination at the Ultrasound Department of Beijing Chaoyang Hospital, Capital Medical University, were selected for this study. All patients underwent strain elastography. Based on changes in their clinical conditions within 30 days following cerebral infarction, they were divided into a deterioration group and a non-deterioration group. The differences between the two groups in terms of strain elastography results were compared for statistical significance. Logistic regression analysis was conducted to analyze factors affecting short-term clinical changes in patients with cerebral infarction. The receiver operating characteristic (ROC) curve was drawn. Results: A total of 110 patients were included in this study (83 males and 27 females, average age: 60.02±10.67 years). The carotid plaque strain elastography value, arterial wall strain elastography value and plaque stiffness were1.17±0.40, 0.53±0.16 and 2.33±0.97 in the deterioration group, 1.73±0.58, 0.59±0.18 and 3.04±1.00 in the non-deterioration group. The differences between the two groups were statistically significant about carotid plaque strain elastography value and plaque stiffness. The AUC values for predicting non-deterioration after cerebral infarction were 0.790 for carotid plaque strain elastography value, 0.608 for arterial wall strain elastography value, and 0.740 for plaque stiffness. Conclusion: Carotid plaque ultrasound strain elastography can be utilized to assess short-term clinical changes after cerebral infarction. Patients who experience clinical deterioration have lower carotid plaque strain elastography values, indicating that this parameter is more effective in predicting the absence of deterioration after cerebral infarction.
Keywords: carotid plaque, Ultrasound strain elastography, Cerebral Infarction, clinicaldeterioration, Short-term prognosis
Received: 23 Jun 2025; Accepted: 22 Aug 2025.
Copyright: © 2025 Li, Weng, Song and Ge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huiyu Ge, Beijing Chaoyang Hospital Affiliated to Capital Medical University Department of Ultrasound Medicine, Beijing, China
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