ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1653647
Effects of Microsurgery on Short-Term Serum Neurotransmitter Levels and Long-Term Cerebral Neurological Function in Elderly Patients with Spontaneous Intracerebral Hemorrhage
Provisionally accepted
- 1Tianjin Medical University, Tianjin, China
- 2Fuzhou University Affiliated Provincial Hospital, Fuzhou, China
- 3Tianjin Huanhu Hospital, Tianjin, China
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Objective: This study explores the impact of microsurgery on postoperative serum neurotransmitter levels and long-term neurological outcomes in elderly spontaneous intracerebral hemorrhage (SICH) patients. Methods: A single-center, prospective, and single-arm cohort study was conducted, enrolling 106 elderly SICH patients aged ≥60 years who underwent microsurgical hematoma evacuation within 24 hours of onset. Serum levels of glutamate (Glu), gamma-aminobutyric acid (GABA), norepinephrine (NE), and serotonin (5-hydroxytryptamine, 5-HT) were measured before surgery and on postoperative day 7. Neurological outcomes were assessed at 180 days using the modified Rankin Scale (mRS) and Glasgow Outcome Scale (GOS). Subgroup analyses were performed based on hematoma volume (≥30 mL vs. <30 mL), hemorrhage location (basal ganglia, thalamus, or lobar), and preoperative Glasgow Coma Scale (GCS) scores (3-8, 9-12, or 13-15). Pearson correlation analysis evaluated the relationship between neurotransmitter levels and outcomes. Results: On postoperative day 7, Glu and NE levels decreased, while GABA and 5-HT levels increased. Larger hematoma volume, lobar location, and moderate GCS (9–12) were associated with higher Glu/NE, lower GABA/5-HT, and worse mRS/GOS scores. Glu and NE levels positively correlated with mRS and negatively with GOS (p < 0.05); opposite trends were seen with GABA and 5-HT. A composite neurotransmitter score showed good prognostic accuracy, with an AUC of 0.894 (95% CI: 0.796–0.992) for mRS > 2 and 0.846 (95% CI: 0.782–0.910) for GOS < 4. Conclusion: Following microsurgical hematoma evacuation in elderly SICH patients, postoperative neurotransmitter profiles were associated with long-term functional outcomes. Persistently high Glu/NE and low GABA/5-HT levels predicted poor recovery, especially in those with large or lobar hematomas.
Keywords: Microsurgery, Spontaneous intracerebral hemorrhage, neurotransmitters, Cerebral neurological function, Long-term functional outcomes
Received: 25 Jun 2025; Accepted: 21 Aug 2025.
Copyright: © 2025 Zhang, Pan, Liao and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shaoya Yin, Tianjin Huanhu Hospital, Tianjin, China
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