ORIGINAL RESEARCH article
Front. Neurol.
Sec. Dementia and Neurodegenerative Diseases
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1655944
Association of hemorrhoidal disease with dementia risk: A nationwide cohort study
Provisionally accepted
- 1Department of Neurology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
- 2Department of Neurology, Ewha Womans University College of Medicine, Seoul, Republic of Korea
- 33Department of Statistics, Yeungnam University College, Daegu, Republic of Korea
- 4Department of Family medicine, Ewha Womans University College of Medicine, Seoul, Republic of Korea
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Research on the association between hemorrhoidal diseases (HDs) and dementia is limited. We explored this relationship in a population-based longitudinal cohort and proposed that individuals with HD may experience a higher incidence of dementia. Our study included 381,031 participants drawn from results from the South Korean health-screening cohort database, between 2005 and 2010. HD was identified based on at least two claims using the International Classification of Diseases, Tenth Revision (ICD-10) code I84. We used propensity score matching (PSM) to categorize the participants into two groups based on the presence or treatment of HD. The primary outcome was the incidence of all-cause dementia as determined by two or more claims with ICD-10 codes (F00-03, G30, and G31). Secondary outcomes included the occurrence of Alzheimer's (F00 or G30) and vascular dementia (F01). Over a median follow-up period of 15.49 years (interquartile range: 12.21–18.77 years), the cumulative incidence of all-cause dementia was 80,488 cases (22.47%). Multivariate analysis showed that the group with HD consistently had a higher incidence of all-cause dementia than the group without HD after PSM (hazard ratio [HR], 1.243; 95% confidence interval [CI], 1.199–1.288). Participants who underwent surgical procedures or treatment for HD revealed a significantly lower incidence of all-cause dementia after PSM (HR, 0.925; 95% CI, 0.872–0.981). This study revealed a significantly higher incidence of all-cause dementia among participants with hemorrhoidal disease, suggesting that while hemorrhoidal disease may not directly cause dementia, it may serve as a marker of an underlying systemic condition that increases dementia risk.
Keywords: Hemorrhoids, Dementia, Epidemiology, Veins, Treatment
Received: 29 Jun 2025; Accepted: 19 Sep 2025.
Copyright: © 2025 Woo, Park, Park, Chun and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tae-Jin Song, knstar@ewha.ac.kr
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