Current Perspectives on the Early Identification and Management of Delirium After Acute Stroke Reperfusion Therapy

Ya-Nan Hao¹Xiao-Yang Feng²Fei Wu³Xiao-Dan Yang^1*Xiao-Ling Zhang^4*

• ¹The Second Affiliated Hospital of Jiaxing University, Jiaxing, China
• ²Zhejiang Province People’s Hospital Haining Hospital, Jiaxing, China
• ³Jiaxing University Master Degree Cultivation Base, Zhejiang Chinese Medical University, Hangzhou, China
• ⁴Center of Rehabilitation Medicine, The Second Affiliated Hospital of Jiaxing University, The Second Hospital of Jiaxing, Jiaxing, Zhejiang, Jiaxing, China

Delirium is a common and severe complication following acute cerebral ischemic stroke reperfusion, affecting cognitive and motor recovery and associated with poor long-term outcomes, prolonged hospitalization, increased readmission, and higher mortality. Identifying risk factors, understanding the pathogenesis (especially reperfusion injury), and implementing early intervention are crucial. However, the complex etiology and limited efficacy of drug treatments make early detection and management challenging. Recent studies have identified factors such as age, NIHSS score, pre-stroke cognition, and post-reperfusion inflammation, along with biomarkers, as predictors of delirium. Family involvement and environmental optimization may also reduce risk. This review summarizes current evidence on risk factors, pathogenesis, biomarkers, and interventions to improve early identification, reduce disability, and improve prognosis.