ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1666940
This article is part of the Research TopicAdvancements in Fluid-Structural Interaction Models for Cerebrovascular HealthView all articles
Association Between Serum Albumin-to-Globulin Ratio and Subtypes of Cerebral Atherosclerotic Stenosis in Acute Ischemic Stroke
Provisionally accepted
- First Affiliated Hospital of Jilin University, Changchun, China
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Background The albumin-to-globulin ratio (AGR) is a biomarker reflecting both nutritional status and inflammation, which has recently been implicated in the development of ischemic stroke. However, its potential association with the occurrence of cerebrovascular stenosis remains unclear. This study aimed to investigate the relationship between AGR and the incidence of cerebral atherosclerotic stenosis. Methods Data from 766 adult patients with acute ischemic stroke (AIS) were included in this cross-sectional analysis. Binary logistic regression was used to evaluate the independent association between AGR and the risk of various cerebrovascular stenosis, including anterior circulation stenosis, posterior circulation stenosis, intracranial and extracranial stenosis. To explore the potential non-linear relationship between AGR and these outcomes, restricted cubic spline models were employed to further clarify these associations. Stratified analyses by body mass index (BMI), age, and sex were additionally conducted to explore the correlation between AGR and cerebral atherosclerotic stenosis under different conditions. Results Patients with cerebral atherosclerotic stenosis had lower AGR levels than those without corresponding vascular stenosis. After adjusting for multiple covariates, AGR levels were negatively associated with the presence of stenosis in the posterior circulations (OR = 0.59, 95%CI = 0.38~0.90, p = 0.015) and intracranial stenosis (Q4: OR = 0.55, 95% CI = 0.34~0.89, p = 0.015). This association was essentially unaffected by BMI, age, or sex. Furthermore, a negative linear relationship was observed between AGR levels and the occurrence of posterior circulation stenosis (p for overall = 0.001, p for nonlinear = 0.228) and intracranial vascular stenosis (p for overall < 0.001, p for nonlinear = 0.440). Conclusions Higher AGR is associated with a reduced risk of multiple cerebral atherosclerotic stenosis. AGR levels are significantly associated with the presence of specific stenosis subtypes and could be hypothesized as a marker for risk stratification; this utility requires validation in prospective cohorts.
Keywords: Albumin-to-globulin ratio, Acute ischemic stroke, Cerebral atherosclerotic stenosis, Posterior Circulation Stenosis, intracranial vascular stenosis
Received: 29 Jul 2025; Accepted: 26 Sep 2025.
Copyright: © 2025 Fu, CAO, Yin, Lang, Su and Cui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li Cui, lcui@jlu.edu.cn
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