ORIGINAL RESEARCH article
Front. Neurol.
Sec. Cognitive and Behavioral Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1667246
Cognitive and Cerebral Perfusion Outcomes Following Interventional Revascularization in Individuals with Chronic Middle Cerebral Artery Occlusion
Provisionally accepted
- 1The First Affiliated Hospital, Anhui Medical University,, HE FEI, China
- 2The First Affiliated Hospital of Bengbu Medical University, Bengbu, China
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Abstract Background Chronic occlusion of the middle cerebral artery (MCAO) is frequently underdiagnosed due to mild or insidious clinical manifestations. Despite this, individuals with chronic MCAO are at an increased risk of cerebral infarction and progressive cognitive impairment. This study aimed to assess the efficacy of interventional revascularization therapy in comparison to standard medical treatment, with a focus on neurological and cognitive outcomes. Methods Fifty-five patients diagnosed with chronic MCAO were allocated to either a medication group or an interventional surgery group. Neurological status and cerebral perfusion parameters, including cerebral blood flow (CBF), time-to-maximum (Tmax), mean transit time (MTT), and cerebral blood volume (CBV) were assessed. Cognitive performance was assessed using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). Post-treatment and follow-up data were collected and analyzed. Results Among the participants in the interventional surgery group, successful recanalization was achieved in 26 cases, while 3 procedures were unsuccessful. Improvements in neurological deficits were observed in both groups. However, significant enhancements in cerebral perfusion parameters (CBF, Tmax, and MTT) and cognitive scores (MoCA and MMSE) were identified only in the interventional group. No statistically significant changes in cerebral perfusion or cognitive performance were observed in the medical therapy group. Conclusion Interventional revascularization therapy was associated with improved cerebral perfusion and enhanced cognitive outcomes compared to medical management in individuals with chronic MCAO.
Keywords: Cerebral perfusion parameters, chronic MCAO, cognitive impairment, Interventional surgery, MOCA score
Received: 16 Jul 2025; Accepted: 20 Oct 2025.
Copyright: © 2025 Yin, Sui, Li, Xu, Xu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xianwen Chen, xianwenchencxwcc@126.com
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