ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1670811
Correlating the Triglyceride Glucose Index (TYG) with Short-Term Neurological and Functional Prognosis Following Intravenous Thrombolysis in Acute Ischemic Stroke Patients
Provisionally accepted
Defeng Hua
Zhen Guo*- Weifang People's Hospital, Weifang, China
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Objective: To assess the correlation between the Triglyceride Glucose (TyG) index and short-term neurological and functional outcomes in patients with acute ischemic stroke (AIS) post-intravenous thrombolysis (IVT). Methods: This prospective observational study included AIS patients treated with IVT within 4.5 hours from symptom onset. The TyG index was calculated using fasting triglyceride and glucose levels. Neurological improvement was evaluated by a reduction in National Institutes of Health Stroke Scale (NIHSS) scores, and functional outcome by modified Rankin Scale (mRS) at discharge. Statistical analysis included correlation and regression analyses. Results: Among 150 AIS patients, the TyG index significantly correlated with both NIHSS (rho=0.45, p<0.01) and mRS (rho=0.38, p<0.01) scores at discharge. A higher TyG index was associated with neurological non-improvement (OR=2.11, p=0.002) and poor functional outcomes (OR=1.89, p=0.005) after adjustment for confounders. Conclusion: The TyG index is significantly associated with short-term outcomes in AIS patients post-IVT, suggesting its potential as a prognostic marker for stroke severity and recovery. Future studies with larger cohorts are needed to confirm these findings.
Keywords: TriglycerideGlucoseIndex, acuteischemicstroke, intravenousthrombolysis, neurological outcomes, functional outcomes
Received: 29 Jul 2025; Accepted: 16 Sep 2025.
Copyright: © 2025 Hua and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhen Guo, 3867927772@qq.com
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