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SYSTEMATIC REVIEW article

Front. Neurol.

Sec. Headache and Neurogenic Pain

Volume 16 - 2025 | doi: 10.3389/fneur.2025.1673321

Determining the Efficacy and Safety of Acupuncture for the Treatment of Menstrual Migraine: An Updated Systematic Review and Meta-Analysis

Provisionally accepted
  • 1Wenzhou Central Hospital, Wenzhou, China
  • 2Zhejiang Rehabilitation Medical Center, Hangzhou, China
  • 3Quzhou Hospital of Traditional Chinese Medicine, Quzhou, China
  • 4Zhejiang Chinese Medical University Affiliated Third Hospital, Hangzhou, China

The final, formatted version of the article will be published soon.

Background: Menstrual migraine (MM) is a common type of headache linked to hormonal fluctuations during the menstrual cycle, remains challenging to treat due to the limited efficacy of current therapies. While acupuncture shows potential as a therapeutic option for MM, the existing evidence does not clearly support its routine clinical use. This protocol for a systematic review and meta-analysis seeks to gather and evaluate recent clinical evidence regarding the effectiveness and safety of acupuncture in treating MM. Methods: A comprehensive search was conducted across multiple databases from their inception to April 2025, including PubMed, Medline, Ovid, Embase, ScienceDirect, the Chinese National Knowledge Infrastructure, Wanfang, the Chinese Biomedical Literature database, and the VIP Database. This was complemented by regular updates from trial registries such as the Cochrane Central Register of Controlled Trials, and the WHO International Clinical Trials Registry Platform, which target unpublished and ongoing randomized controlled trials (RCTs). Eligible studies were RCTs comparing acupuncture with Western medicine, herbal remedies, sham acupuncture, or no intervention for the management of MM. Primary outcomes included the pain intensity (Visual Analogue Scale), the frequency of migraine attacks (FM), and duration of migraine. Secondary outcomes encompassed response rate, Headache Impact Test-6 (HIT-6), the Menstrual Headache Index, the serum levels of 5-hydroxytryptamine, and adverse events. Analyses involved meta-analysis, subgroup comparisons, publication bias detection, sensitivity testing, risk-of-bias evaluations, and profiling of adverse events. The quality of evidence was judged according to the GRADE criteria. Results: A total of 39 RCTs comprising 2584 participants were included. Compared with control interventions, acupuncture significantly reduced VAS scores, decreased the frequency and duration of migraine attacks, and improved response rates, as well as HIT-6 and MHI scores. Additionally, acupuncture was associated with increased serum 5-HT levels. Meta-analytic findings indicated that acupuncture demonstrated a favorable safety profile in the treatment of MM. Conclusion: Findings suggest that acupuncture for MM produced the most notable reductions in migraine severity. Nevertheless, the GRADE assessment indicated low overall certainty of the evidence, with considerable heterogeneity present in multiple pooled analyses. Therefore, well-designed, large-scale RCTs are urgently required to strengthen the evidence base.

Keywords: Menstrual migraine, Acupuncture, Systematic review, Meta-analysis, Headache

Received: 28 Jul 2025; Accepted: 31 Aug 2025.

Copyright: © 2025 Wu, Fan, Wu, Gao, Han, Hu and Qian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Hantong Hu, Zhejiang Chinese Medical University Affiliated Third Hospital, Hangzhou, China
Lala Qian, Wenzhou Central Hospital, Wenzhou, China

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