ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neuroepidemiology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1673606
Exploring the Stroke Burden Linked to Kidney Dysfunction: Trends, Predictive Insights, and Health Inequalities
Provisionally accepted
- 1Zhejiang Chinese Medical University, Hangzhou, China
- 2Zhejiang Hospital, Hangzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Over the past 30 years, the prevalence of kidney disease has increased, underscoring the need to address the stroke burden linked to kidney dysfunction. This study aims to analyze trends and factors underlying the stroke burden and its subtypes attributable to kidney dysfunction from 1990 to 2021. Methods: In this study, we used Global Burden of Disease data to assess stroke burden attributable to kidney dysfunction within the GBD framework. Methods included joinpoint models, decomposition analysis, age-period-cohort models, Bayesian models, and health inequality analysis. Results: The burden of stroke attributable to kidney dysfunction remains significant, with aging as a key factor. By 2021, such strokes caused 676.1×10³ (95% CI: 467.78×10³, 896.74×10³) deaths and 15009.65×10³ (95% CI: 10939.08×10³, 19133.72×10³) DALYs globally. Males experience a higher burden (ASMR of 9.16 and ASDR of 200.83 per 100,000) compared to females (ASMR of 7.17 and ASDR of 150.63 per 100,000). The burden is concentrated in low SDI countries, with trends intensifying for total and ischemic strokes. Projections suggest a decline in overall burden, but an increase in ischemic stroke among younger populations. Conclusions: The global stroke burden attributable to kidney dysfunction remains significant, with regional disparities. Public health authorities should create targeted guidelines considering economic levels, stroke subtypes, gender, and age to effectively mitigate this burden.
Keywords: Global burden of disease, Kidney dysfunction, Stroke, socio-demographic index, Inequality
Received: 15 Aug 2025; Accepted: 14 Oct 2025.
Copyright: © 2025 Tang, Lu, Shunan, Wan and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shu Wan, wanshu@zju.edu.cn
Ming Wang, minghui0507@zju.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.