REVIEW article
Front. Neurol.
Sec. Neurotrauma
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1678839
This article is part of the Research TopicIntegrative Approaches to Acute Brain Injury: Vascular, Electrical, and Metabolic InteractionsView all 10 articles
Mechanisms and Potential Therapeutic Molecular Targets in Blood-Brain Barrier Disruption Following Subarachnoid Hemorrhage: A Review of Early Brain Injury
Provisionally accepted
- 1Zhejiang Chinese Medical University, Hangzhou, China
- 2The First People's Hospital of Huzhou, Huzhou, China
- 3Changsha Medical University, Changsha, China
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Subarachnoid hemorrhage (SAH) is a devastating stroke characterized by acute onset, severe symptoms, and a poor prognosis. A series of pathological changes occur within 72 hours after SAH, leading to early brain injury (EBI). Blood-brain barrier (BBB) disruption is a key factor contributing to the EBI progression. When the BBB is compromised, detrimental substances and immune cells have the potential to infiltrate brain tissues, and a range of mechanisms contribute to the disruption of the BBB following SAH. This review provides a comprehensive overview of the current knowledge regarding the underlying mechanisms and potential therapeutic targets in BBB disruption during EBI following SAH. It focuses on the dysfunction of endothelial cells, tight junctions, astrocytes, and pericytes; the specific molecular targets for EBI after SAH; and new emerging treatments for BBB disruption in EBI after SAH.
Keywords: hemorrhagic stroke, Intracranial Aneurysm, Brain Edema, neuron apoptosis, Brain herniation, Endothelial Cells, Pericytes, Astrocytes
Received: 03 Aug 2025; Accepted: 03 Oct 2025.
Copyright: © 2025 Ouyang, Gu, Cai and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hua Gu, neurosurgerygh@zjhu.edu.cn
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