ORIGINAL RESEARCH article
Front. Neurol.
Sec. Endovascular and Interventional Neurology
A Study on the Value of the Relationship Between Newly Occurring Microinfarctions After Stent-Assisted Treatment for Unruptured Intracranial Aneurysms and Systemic Inflammatory Immune Indices
Provisionally accepted
- The First Affiliated Hospital of Bengbu Medical University, Bengbu, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background A paucity of studies has been conducted on the relationship between new microinfarctions following stent-assisted treatment for unruptured intracranial aneurysms (UIA) and systemic inflammatory indices (SII) derived from complete blood counts (CBC) and clinical outcomes. The objective of this study was to assess the possible relationship between SII and the occurrence of new postoperative infarcts. Methods A total of 64 patients who underwent UIA stent-assisted therapy at the Department of Neurosurgery, First Affiliated Hospital of Bengbu Medical University, from January 2024 to July 2025 were selected as the study subjects. Blood tests, systemic inflammatory markers (NMP :(Neutrophil Count* Monocyte Count), PLR :(Platelet count/Lymphocyte count), SII :((Neutrophil Count*Platelet Count)/Lymphocyte Count), and cranial MRI-DWI were collected at admission and on the third day post-surgery. Patients were divided into two groups, positive and negative, based on the presence of new microinfarctions. Results Among the 64 patients included in the study, 24 (37.5%) MRI-DWI reveals new microinfarcts, while 40 (62.5%) MRI-DWI showed no evidence of new microinfarcts. A comparative analysis of the third day postoperatively reveals that white blood cell count, neutrophil count, PLR, and SII increased, while lymphocyte count decreased. The neutrophil count, lymphocyte count, PLR, and SII on the third day postoperatively were found to be associated with the occurrence of new microinfarctions. Third-day SII was independently correlated with new microinfarctions that occurred after UIA stent-assisted therapy. Conclusion SII may serve as a potential indicator of the association between postoperative inflammatory response and microinfarction events, with elevated postoperative SII levels correlating with the occurrence of new microinfarctions following UIA stenting procedures.
Keywords: Unruptured intracranial aneurysm, Interventional therapy, Newly developed micro infarcted lesions, Systemic immune inflammatory index, Inflammation
Received: 04 Aug 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Lv, li, han, zhang, Li and xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: jian li, byfylj@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.